Detailed view for Smp_166310

Basic information

TDR Targets ID: 284165
Schistosoma mansoni, ran gtpase-activating protein
Source Database / ID:  GeneDB

pI: 4.4563 | Length (AA): 688 | MW (Da): 75084 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13516   Leucine Rich repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005096   GTPase activator activity  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 326 2ca6 (A) 5 315 36.00 0 1 0.975642 -0.98
25 164 1io0 (A) 180 314 28.00 0.31 1 0.585188 -0.99
32 364 4r5d (A) 77 415 27.00 0.00000000075 1 0.734712 0.12
57 262 5irm (A) 814 998 34.00 0.0000000087 1 0.660119 -0.48
211 277 5irn (A) 947 1013 31.00 0 1 0.573984 -0.89
288 349 4z5w (A) 112 167 43.00 0.72 0.66 0.427816 0.51
371 432 4r4g (A) 185 246 16.00 0 0.08 0.487716 -2.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129148)

Species Accession Gene Product
Arabidopsis thaliana AT3G63130   RAN GTPase-activating protein 1
Arabidopsis thaliana AT5G19320   RAN GTPase-activating protein 2
Brugia malayi Bm1_45950   Leucine Rich Repeat family protein
Candida albicans CaO19.1649   similar to GAP for Gsp1p (Ran), nuclear export
Candida albicans CaO19.9218   similar to GAP for Gsp1p (Ran), nuclear export
Caenorhabditis elegans CELE_C29E4.3   Protein RAN-2, isoform B
Dictyostelium discoideum DDB_G0283683   leucine-rich repeat-containing protein
Drosophila melanogaster Dmel_CG9999   Ran GTPase activating protein
Echinococcus granulosus EgrG_000100600   ran GTPase activating protein 1
Echinococcus multilocularis EmuJ_000100600   ran GTPase activating protein 1
Homo sapiens ENSG00000100401   Ran GTPase activating protein 1
Loa Loa (eye worm) LOAG_12482   hypothetical protein
Loa Loa (eye worm) LOAG_15287   hypothetical protein
Mus musculus ENSMUSG00000022391   RAN GTPase activating protein 1
Oryza sativa 4339487   Os05g0543200
Saccharomyces cerevisiae YMR235C   Rna1p
Schistosoma japonicum Sjp_0051250   Ran GTPase-activating protein 1, putative
Schistosoma mansoni Smp_166310   ran gtpase-activating protein
Schmidtea mediterranea mk4.000788.00   Putative ran gtpase-activating protein

Essentiality

Smp_166310 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C29E4.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_C29E4.3 Caenorhabditis elegans sterile wormbase
YMR235C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_166310 (Schistosoma mansoni), ran gtpase-activating protein
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