Detailed view for Smp_137330

Basic information

TDR Targets ID: 284429
Schistosoma mansoni, threonine dehydratase
Source Database / ID:  GeneDB

pI: 6.5689 | Length (AA): 956 | MW (Da): 103890 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00076   RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00291   Pyridoxal-phosphate dependent enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  
GO:0003723   RNA binding  
GO:0003676   nucleic acid binding  
GO:0000166   nucleotide binding  
GO:0008152   metabolic process  
GO:0006520   amino acid metabolic process  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 326 5vsu (A) 27 231 21.00 0.000012 1 0.249397 0.14
74 153 5w0h (A) 257 336 30.00 0.0031 1 0.667882 -1.94
74 211 1fxl (A) 37 160 44.00 0 1 0.566551 -0.02
421 812 2c2b (A) 46 432 19.00 0 1 0.578242 -0.02
481 944 1tdj (A) 5 456 22.00 0 1 0.647556 0.44
503 828 1pwh (A) 5 319 38.00 0 1 0.886004 -1.32
507 829 2rkb (A) 16 326 41.00 0 1 0.878866 -1.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129794)

Species Accession Gene Product
Candida albicans CaO19.7404   catabolic serine/threonine dehydratase
Candida albicans CaO19.9548   catabolic serine/threonine dehydratase
Candida albicans CaO19.1997   catabolic serine/threonine dehydratase
Candida albicans CaO19.1996   see CaP19.1997
Dictyostelium discoideum DDB_G0272787   L-serine ammonia-lyase
Echinococcus granulosus EgrG_001093200   l serine dehydratase:l threonine deaminase
Echinococcus multilocularis EmuJ_001093200   l serine dehydratase:l threonine deaminase
Homo sapiens ENSG00000135094   serine dehydratase
Homo sapiens ENSG00000139410   serine dehydratase-like
Mus musculus ENSMUSG00000029596   serine dehydratase-like
Mus musculus ENSMUSG00000029597   serine dehydratase
Saccharomyces cerevisiae YCL064C   L-serine/L-threonine ammonia-lyase CHA1
Schistosoma japonicum Sjp_0057880   ko:K01754 threonine dehydratase [EC4.3.1.19], putative
Schistosoma mansoni Smp_137330   threonine dehydratase
Schmidtea mediterranea mk4.012979.00   Serine dehydratase, putative
Schmidtea mediterranea mk4.009509.00   Serine dehydratase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Mycobacterium tuberculosis Cysteine synthase a CysK1 (O-acetylserine sulfhydrylase A) (O-acetylserine (thiol)-lyase A) (CSASE A) 310 aa 25.3% 312 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_137330 (Schistosoma mansoni), threonine dehydratase
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