Detailed view for Smp_174470

Basic information

TDR Targets ID: 284481
Schistosoma mansoni, mannosyl-oligosaccharidealpha-12-mannosidase-r el ated
Source Database / ID:  GeneDB

pI: 6.0497 | Length (AA): 947 | MW (Da): 107013 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01532   Glycosyl hydrolase family 47
PF02225   PA domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004571   mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  
GO:0016020   membrane  
GO:0005509   calcium ion binding  
GO:0003824   catalytic activity  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 445 4ayo (A) 43 459 27.00 0 1 0.849305 -1.09
1 444 1x9d (A) 256 695 36.00 0 1 0.811249 -0.43
1 444 1nxc (A) 204 642 34.00 0 1 0.727249 -0.29
2 448 2ri9 (A) 1048 1510 31.00 0 1 0.781417 -0.6
594 766 3icu (A) 48 185 18.00 0 0.93 0.0980822 0.75
639 785 4tjx (A) 44 179 21.00 0 0.86 0.283627 0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132081)

Species Accession Gene Product
Brugia malayi Bm1_05110   Alpha-mannosidase C1orf22
Brugia malayi Bm1_23615   Alpha-mannosidase C1orf22
Brugia malayi Bm1_11230   Alpha-mannosidase C1orf22
Caenorhabditis elegans CELE_ZC506.1   Protein ZC506.1
Drosophila melanogaster Dmel_CG5682   CG5682 gene product from transcript CG5682-RA
Echinococcus granulosus EgrG_000807400   er degradation enhancing alpha mannosidase
Echinococcus multilocularis EmuJ_000807400   er degradation enhancing alpha mannosidase er degradation enhancer mannosidase alpha
Homo sapiens ENSG00000116406   ER degradation enhancer, mannosidase alpha-like 3
Loa Loa (eye worm) LOAG_03306   hypothetical protein
Mus musculus ENSMUSG00000043019   ER degradation enhancer, mannosidase alpha-like 3
Schistosoma japonicum Sjp_0002490   ko:K10086 ER degradation enhancer, mannosidase alpha-like 3, putative
Schistosoma japonicum Sjp_0002480   ER degradation-enhancing alpha-mannosidase-like 3 precursor, putative
Schistosoma japonicum Sjp_0304570   ER degradation-enhancing alpha-mannosidase-like 3 precursor, putative
Schistosoma mansoni Smp_174470   mannosyl-oligosaccharidealpha-12-mannosidase-r el ated
Schmidtea mediterranea mk4.004781.03   ER degradation-enhancing alpha-mannosidase-like protein 3
Schmidtea mediterranea mk4.029596.00   ER degradation-enhancing alpha-mannosidase-like protein 3
Schmidtea mediterranea mk4.030982.00   ER degradation-enhancing alpha-mannosidase-like protein 3
Schmidtea mediterranea mk4.023644.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Glycine max Alpha-mannosidase 578 aa 32.1% 476 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_174470 (Schistosoma mansoni), mannosyl-oligosaccharidealpha-12-mannosidase-r el ated
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