pI: 7.155 |
Length (AA): 357 |
MW (Da): 41376 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
235 | 277 | 2yqq (A) | 14 | 54 | 51.00 | 0 | 0.74 | 0.631648 | 0.01 |
288 | 356 | 5l85 (A) | 82 | 150 | 39.00 | 0.000000047 | 1 | 0.779777 | -1.02 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130154)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G28820 | HIT-type zinc finger protein |
Babesia bovis | BBOV_I002100 | hypothetical protein |
Candida albicans | CaO19.2723 | protein required for growth at high temperature |
Candida albicans | CaO19.10238 | similar to S. cerevisiae HIT1: protein degradation pathway |
Cryptosporidium hominis | Chro.80314 | hypothetical protein |
Cryptosporidium parvum | cgd8_2690 | hypothetical protein |
Dictyostelium discoideum | DDB_G0282901 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8204 | CG8204 gene product from transcript CG8204-RA |
Echinococcus granulosus | EgrG_000728700 | Zinc finger HIT domain containing protein 3 |
Entamoeba histolytica | EHI_148030 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000728700 | Zinc finger HIT domain containing protein 3 |
Homo sapiens | ENSG00000273611 | zinc finger, HIT-type containing 3 |
Mus musculus | ENSMUSG00000020526 | zinc finger, HIT type 3 |
Plasmodium berghei | PBANKA_0817900 | zinc finger protein, putative |
Plasmodium falciparum | PF3D7_0916900 | zinc finger protein, putative |
Plasmodium knowlesi | PKNH_0714900 | zinc finger protein, putative |
Plasmodium vivax | PVX_099265 | hypothetical protein, conserved |
Plasmodium yoelii | PY03266 | hypothetical protein |
Saccharomyces cerevisiae | YJR055W | Hit1p |
Schistosoma japonicum | Sjp_0208390 | Zinc finger HIT domain-containing protein 3, putative |
Schistosoma japonicum | Sjp_0047100 | expressed protein |
Schistosoma mansoni | Smp_073950 | hypothetical protein |
Theileria parva | TP03_0121 | hypothetical protein |
Trichomonas vaginalis | TVAG_328490 | conserved hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.