Detailed view for Smp_158380

Basic information

TDR Targets ID: 284668
Schistosoma mansoni, mitochondrial import inner membrane translocase subunit tim44

Source Database / ID:  GeneDB

pI: 7.2373 | Length (AA): 407 | MW (Da): 47357 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04280   Tim44-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005744   mitochondrial inner membrane presequence translocase complex  
GO:0051087   chaperone binding  
GO:0015450   P-P-bond-hydrolysis-driven protein transmembrane transporter activity  
GO:0030150   protein import into mitochondrial matrix  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 178 6ek4 (A) 146 296 14.00 0 0.12 0.587421 -1.3
26 203 4uos (A) 9 184 19.00 0.0003 0.44 0.714946 -1.61
26 183 3g67 (A) 95 244 29.00 0.4 0.11 0.570906 -0.08
225 405 2cw9 (A) 270 450 54.00 0 1 1.16232 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128571)

Species Accession Gene Product
Arabidopsis thaliana AT2G20510   translocase inner membrane subunit 44-1
Arabidopsis thaliana AT2G36070   translocase inner membrane subunit 44-2
Babesia bovis BBOV_IV008230   mitochondrial inner membrane translocase subunit TIM44, putative
Brugia malayi Bm1_25440   hypothetical protein
Brugia malayi Bm1_27035   Tim44-like domain containing protein
Candida albicans CaO19.5444   involved in mitochondrial protein import
Candida albicans CaO19.12899   involved in mitochondrial protein import
Caenorhabditis elegans CELE_T09B4.9   Protein T09B4.9
Cryptosporidium hominis Chro.30332   mitochondrial import inner membrane translocase
Cryptosporidium parvum cgd3_2930   possible mitochondrial import inner membrane, translocase subunit TIM44
Drosophila melanogaster Dmel_CG11779   CG11779 gene product from transcript CG11779-RB
Echinococcus granulosus EgrG_001192100   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_001192100   mitochondrial import inner membrane translocase
Homo sapiens ENSG00000104980   translocase of inner mitochondrial membrane 44 homolog (yeast)
Loa Loa (eye worm) LOAG_12034   zinc finger protein
Loa Loa (eye worm) LOAG_10876   hypothetical protein
Mus musculus ENSMUSG00000002949   translocase of inner mitochondrial membrane 44
Neospora caninum NCLIV_045570   hypothetical protein
Oryza sativa 4343001   Os07g0409700
Plasmodium berghei PBANKA_0922900   mitochondrial import inner membrane translocase subunit TIM44, putative
Plasmodium falciparum PF3D7_1125400   mitochondrial import inner membrane translocase subunit TIM44, putative
Plasmodium knowlesi PKNH_0923300   mitochondrial import inner membrane translocase subunit TIM44, putative
Plasmodium vivax PVX_091890   mitochondrial import inner membrane translocase subunit TIM44, putative
Plasmodium yoelii PY06558   Drosophila melanogaster CG11779 gene product, putative
Saccharomyces cerevisiae YIL022W   Tim44p
Schistosoma japonicum Sjp_0302350   Import inner membrane translocase subunit TIM44, mitochondrial precursor, putative
Schistosoma mansoni Smp_158380   mitochondrial import inner membrane translocase subunit tim44
Schmidtea mediterranea mk4.001039.02   Probable mitochondrial import inner membrane translocase subunit tim-44
Toxoplasma gondii TGME49_227830   mitochondrial inner membrane translocase TIM44, putative
Theileria parva TP01_0950   mitochondrial import inner membrane translocase, putative
Trichomonas vaginalis TVAG_008790   conserved hypothetical protein

Essentiality

Smp_158380 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T09B4.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_T09B4.9 Caenorhabditis elegans larval arrest wormbase
CELE_T09B4.9 Caenorhabditis elegans slow growth wormbase
CELE_T09B4.9 Caenorhabditis elegans sterile wormbase
CELE_T09B4.9 Caenorhabditis elegans terminal arrest variable wormbase
YIL022W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0922900 Plasmodium berghei Essential plasmo
TGME49_227830 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_158380 (Schistosoma mansoni), mitochondrial import inner membrane translocase subunit tim44
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