pI: 6.7382 |
Length (AA): 189 |
MW (Da): 21413 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
74 | 149 | 6bo7 (A) | 151 | 228 | 32.00 | 0.055 | 0.03 | 0.467516 | 1.85 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129793)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04200 | signal peptidase subunit-25 |
Arabidopsis thaliana | AT2G39960 | signal peptidase complex subunit 2 |
Brugia malayi | Bm1_28300 | microsomal signal peptidase 25 kDa subunit |
Brugia malayi | Bm1_55525 | hypothetical protein |
Candida albicans | CaO19.11657 | subunit of signal peptidase complex |
Candida albicans | CaO19.4181 | subunit of signal peptidase complex |
Caenorhabditis elegans | CELE_Y37D8A.10 | Protein HPO-21 |
Dictyostelium discoideum | DDB_G0270510 | microsomal signal peptidase subunit |
Drosophila melanogaster | Dmel_CG1751 | Spase 25-subunit |
Echinococcus granulosus | EgrG_000887800 | Probable signal peptidase complex subunit 2 |
Echinococcus multilocularis | EmuJ_000887800 | Probable signal peptidase complex subunit 2 |
Homo sapiens | ENSG00000118363 | signal peptidase complex subunit 2 homolog (S. cerevisiae) |
Loa Loa (eye worm) | LOAG_03110 | microsomal signal peptidase 25 kDa subunit |
Mus musculus | ENSMUSG00000035227 | signal peptidase complex subunit 2 homolog (S. cerevisiae) |
Oryza sativa | 4335967 | Os04g0446300 |
Oryza sativa | 4329702 | Os02g0565200 |
Saccharomyces cerevisiae | YML055W | Spc2p |
Schistosoma japonicum | Sjp_0073580 | ko:K01423 signal peptidase complex subunit 2 homolog [EC:3.4.-.-], putative |
Schistosoma mansoni | Smp_024390.3 | microsomal signal peptidase 25 kD subunit |
Schistosoma mansoni | Smp_024390.2 | microsomal signal peptidase 25 kD subunit |
Schistosoma mansoni | Smp_024390.1 | microsomal signal peptidase 25 kD subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y37D8A.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y37D8A.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y37D8A.10 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y37D8A.10 | Caenorhabditis elegans | sterile | wormbase |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.