Detailed view for Smp_168770

Basic information

TDR Targets ID: 284855
Schistosoma mansoni, mitochondria associated granulocyte macrophage csf signaling molecule
Source Database / ID:  GeneDB

pI: 9.6571 | Length (AA): 134 | MW (Da): 15105 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03656   Pam16

Gene Ontology

Mouse over links to read term descriptions.
GO:0005744   mitochondrial inner membrane presequence translocase complex  
GO:0031072   heat shock protein binding  
GO:0030150   protein import into mitochondrial matrix  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
57 117 2guz (B) 53 116 43.00 0.42 0.99 1.04472 -1.06
63 132 4rwu (A) 8 78 17.00 0 0.42 0.892888 -1.74
67 103 1faf (A) 20 56 22.00 0.48 0.12 0.564619 -0.62

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129619)

Species Accession Gene Product
Arabidopsis thaliana AT5G61880   protein transporter, Pam16
Arabidopsis thaliana AT3G59280   protein THAXTOMIN A RESISTANT 1
Brugia malayi Bm1_19660   Hypothetical UPF0108 protein F45G2.8 in chromosome III, putative
Candida albicans CaO19.7222   similar to S. cerevisiae YJL104W
Caenorhabditis elegans CELE_F45G2.8   Protein F45G2.8
Dictyostelium discoideum DDB_G0282195   mitochondrial import inner membrane translocase subunit 16
Drosophila melanogaster Dmel_CG5268   black pearl
Drosophila melanogaster Dmel_CG1409   CG1409 gene product from transcript CG1409-RB
Echinococcus granulosus EgrG_001028300   mitochondrial import inner membrane translocase
Echinococcus multilocularis EmuJ_001028300   mitochondrial import inner membrane translocase
Homo sapiens ENSG00000217930   presequence translocase-associated motor 16 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_09253   import inner membrane translocase subunit Tim16
Mus musculus ENSMUSG00000014301   presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
Oryza sativa 4348915   Os10g0479600
Oryza sativa 9268634   Os01g0960800
Saccharomyces cerevisiae YJL104W   Pam16p
Schistosoma japonicum Sjp_0032720   Mitochondrial import inner membrane translocase subunit Tim16-A, putative
Schistosoma mansoni Smp_168770   mitochondria associated granulocyte macrophage csf signaling molecule
Schmidtea mediterranea mk4.000426.03   Mitochondrial import inner membrane translocase subunit TIM16
Trichomonas vaginalis TVAG_470110   conserved hypothetical protein

Essentiality

Smp_168770 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F45G2.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_F45G2.8 Caenorhabditis elegans larval arrest wormbase
CELE_F45G2.8 Caenorhabditis elegans sterile wormbase
YJL104W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_168770 (Schistosoma mansoni), mitochondria associated granulocyte macrophage csf signaling molecule
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