Detailed view for Smp_174680

Basic information

TDR Targets ID: 284878
Schistosoma mansoni, diphteria toxin resistance protein 2 dph2
Source Database / ID:  GeneDB

pI: 6.4941 | Length (AA): 538 | MW (Da): 61085 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01866   Putative diphthamide synthesis protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0017183   peptidyl-diphthamide biosynthetic process from peptidyl-histidine  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 421 3lzd (A) 4 334 18.00 0 1 0.708288 0.85
279 396 3lzd (A) 195 309 30.00 0.000044 1 0.549431 -0.2
285 415 4uvj (A) 821 955 33.00 0.31 0.28 0.177594 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129547)

Species Accession Gene Product
Arabidopsis thaliana AT3G59630   diphthamide synthesis DPH2 family protein
Babesia bovis BBOV_IV010430   conserved hypothetical protein
Brugia malayi Bm1_09290   diphthamide biosynthesis protein 2 containing protein
Candida albicans CaO19.1174   almost identical to C terminus of CaP19.4173
Candida albicans CaO19.5678   almost identical to N terminus of CaP19.4173
Candida albicans CaO19.11649   similar to S. cerevisiae Diptheria toxin resistance protein (diphthamide synthesis)
Candida albicans CaO19.4173   similar to S. cerevisiae Diptheria toxin resistance protein (diphthamide synthesis)
Candida albicans CaO19.13123   almost identical to N terminus of CaP19.4173
Caenorhabditis elegans CELE_C09G5.2   Protein DPH-2, isoform B
Dictyostelium discoideum DDB_G0295687   diphthamide biosynthesis protein 2
Drosophila melanogaster Dmel_CG7265   CG7265 gene product from transcript CG7265-RA
Echinococcus granulosus EgrG_000177300   Diphthamide biosynthesis protein 2
Echinococcus multilocularis EmuJ_000177300   Diphthamide biosynthesis protein 2
Homo sapiens ENSG00000132768   DPH2 homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_05316   hypothetical protein
Mus musculus ENSMUSG00000028540   DPH2 homolog (S. cerevisiae)
Oryza sativa 4350247   Os11g0265600
Plasmodium berghei PBANKA_1015200   diphthamide biosynthesis protein 2, putative
Plasmodium falciparum PF3D7_1429500   diphthamide biosynthesis protein 2, putative
Plasmodium knowlesi PKNH_1329200   diphthamide biosynthesis protein 2, putative
Plasmodium vivax PVX_085065   diphthamide synthesis protein, putative
Plasmodium yoelii PY06443   hypothetical protein
Saccharomyces cerevisiae YKL191W   Dph2p
Schistosoma japonicum Sjp_0217450   Diphthamide biosynthesis protein 2, putative
Schistosoma japonicum Sjp_0107680   IPR002728,Diphthamide synthesis DPH2 protein;IPR010014,Diphthamide biosynthesis protein 2,domain-containing
Schistosoma mansoni Smp_174680   diphteria toxin resistance protein 2 dph2
Schmidtea mediterranea mk4.000423.09   Diphthamide biosynthesis protein 2

Essentiality

Smp_174680 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1015200 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_174680 (Schistosoma mansoni), diphteria toxin resistance protein 2 dph2
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