Detailed view for Smp_159490

Basic information

TDR Targets ID: 284925
Schistosoma mansoni, peptidase
Source Database / ID:  GeneDB

pI: 8.4423 | Length (AA): 1860 | MW (Da): 212586 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00535   Glycosyl transferase family 2
PF00557   Metallopeptidase family M24
PF00566   Rab-GTPase-TBC domain
PF00652   Ricin-type beta-trefoil lectin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0017137   Rab GTPase binding  
GO:0008270   zinc ion binding  
GO:0008235   metalloexopeptidase activity  
GO:0005515   protein binding  
GO:0005097   Rab GTPase activator activity  
GO:0004177   aminopeptidase activity  
GO:0032313   regulation of Rab GTPase activity  
GO:0009987   cellular process  
GO:0006886   intracellular protein transport  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 504 2d7i (A) 86 586 49.00 0 1 0.86383 -0.44
3 512 6h0b (A) 72 576 37.00 0 1 0.697594 -0.24
62 159 3bcv (A) 4 93 41.00 0.023 1 0.587588 -1.13
63 180 3bcv (A) 5 114 29.00 0.22 0.99 0.485841 -1.24
366 465 1rzo (B) 2163 2258 33.00 0.55 0.46 0.292663 0.29
372 467 1m2t (B) 417 508 25.00 0 0.97 0.253413 -0.12
551 638 6chg (D) 28 115 28.00 0.45 0.89 0.477212 -0.89
868 1111 4hl4 (A) 46 303 16.00 0 1 0.256983 -0.31
1154 1257 5hmo (A) 808 923 35.00 0.31 0.02 0.177814 1.12
1164 1327 5vjt (A) 21 184 12.00 0 0.02 0.213972 -1.2
1286 1689 4fkc (A) 5 367 17.00 0 1 0.212004 0.44
1362 1711 3s6b (A) 28 359 30.00 0 1 0.476572 -0.19
1383 1721 4fuk (A) 62 394 35.00 0 1 0.418658 0.03
1396 1700 3pka (A) 9 283 36.00 0 1 0.533378 -0.3
1425 1700 4fo7 (A) 2 248 38.00 0 1 0.485787 0.02
1426 1700 1o0x (A) 7 252 30.00 0 1 0.462249 -0.45
1426 1711 3mx6 (A) 2 258 34.00 0 1 0.494163 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130821)

Species Accession Gene Product
Brugia malayi Bm1_39295   glycosyl transferase, group 2 family protein
Caenorhabditis elegans CELE_Y45F10D.3   Protein GLY-10, isoform B
Drosophila melanogaster Dmel_CG2103   polypeptide GalNAc transferase 6
Drosophila melanogaster Dmel_CG31956   polypeptide GalNAc transferase 4
Echinococcus granulosus EgrG_000651700   methionine aminopeptidase type I
Echinococcus granulosus EgrG_000609600   polypeptide GalNAc transferase 6
Echinococcus multilocularis EmuJ_000609600   polypeptide GalNAc transferase 6
Echinococcus multilocularis EmuJ_000651700   methionine aminopeptidase, type I
Homo sapiens 442117   polypeptide N-acetylgalactosaminyltransferase-like 6
Homo sapiens ENSG00000164574   polypeptide N-acetylgalactosaminyltransferase 10
Loa Loa (eye worm) LOAG_00244   glycosyl transferase
Mus musculus 270049   UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
Mus musculus ENSMUSG00000020520   UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10
Schistosoma japonicum Sjp_0090470   IPR000772,Ricin B lectin;IPR008997,Ricin B-related lectin,domain-containing
Schistosoma japonicum Sjp_0097590   WD repeat-containing protein 67, putative
Schistosoma japonicum Sjp_0084010   WD repeat-containing protein 67, putative
Schistosoma japonicum Sjp_0066770   Putative polypeptide N-acetylgalactosaminyltransferase 10, putative
Schistosoma japonicum Sjp_0208560   ko:K00710 polypeptide N-acetylgalactosaminyltransferase [EC2.4.1.41], putative
Schistosoma japonicum Sjp_0215210   ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative
Schistosoma mansoni Smp_057620   n-acetylgalactosaminyltransferase
Schistosoma mansoni Smp_159490   peptidase
Schmidtea mediterranea mk4.014605.00  
Schmidtea mediterranea mk4.007234.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Staphylococcus aureus (strain COL) Methionine aminopeptidase 252 aa 27.6% 268 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_159490 (Schistosoma mansoni), peptidase
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