Detailed view for Smp_171650

Basic information

TDR Targets ID: 284983
Schistosoma mansoni, eps-15-related
Source Database / ID:  GeneDB

pI: 4.5619 | Length (AA): 603 | MW (Da): 67478 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12763   Cytoskeletal-regulatory complex EF hand

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 94 2khn (A) 25 116 27.00 0.0000017 1 0.60947 -1.28
95 204 2khn (A) 15 119 33.00 0 1 0.560221 -0.79
105 201 1c07 (A) 10 103 46.00 0 1 0.764362 -0.87
263 404 3l4q (C) 429 579 16.00 0 0.29 0.431289 -1.53

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128866)

Species Accession Gene Product
Babesia bovis BBOV_IV000260   EF hand domain conatining protein
Brugia malayi Bm1_24945   EF hand family protein
Candida albicans CaO19.1166   potential EF hand protein similar to S. cerevisiae EDE1 (YBL047C) involved in endocytosis
Candida albicans CaO19.8759   potential EF hand protein similar to S. cerevisiae EDE1 (YBL047C) involved in endocytosis
Caenorhabditis elegans CELE_ZK1248.3   Protein EHS-1, isoform B
Dictyostelium discoideum DDB_G0287325   hypothetical protein
Drosophila melanogaster Dmel_CG16932   Epidermal growth factor receptor pathway substrate clone 15
Echinococcus granulosus EgrG_000581800   epidermal growth factor receptor substrate
Echinococcus multilocularis EmuJ_000581800   epidermal growth factor receptor substrate
Homo sapiens ENSG00000127527   epidermal growth factor receptor pathway substrate 15-like 1
Homo sapiens ENSG00000085832   epidermal growth factor receptor pathway substrate 15
Loa Loa (eye worm) LOAG_01791   EF hand family protein
Mus musculus ENSMUSG00000028552   epidermal growth factor receptor pathway substrate 15
Mus musculus ENSMUSG00000006276   epidermal growth factor receptor pathway substrate 15-like 1
Neospora caninum NCLIV_045590   hypothetical protein, conserved
Plasmodium yoelii PY05811   epidermal growth factor receptor substrate 15
Saccharomyces cerevisiae YBL047C   Ede1p
Schistosoma japonicum Sjp_0059410   Epidermal growth factor receptor substrate 15-like 1, putative
Schistosoma mansoni Smp_171650   eps-15-related
Schmidtea mediterranea mk4.008502.00  
Schmidtea mediterranea mk4.033744.00  
Schmidtea mediterranea mk4.038590.00  
Schmidtea mediterranea mk4.039148.00  
Schmidtea mediterranea mk4.000101.14  
Schmidtea mediterranea mk4.023677.00  
Schmidtea mediterranea mk4.024703.00  
Schmidtea mediterranea mk4.042017.00  
Schmidtea mediterranea mk4.004353.01  
Schmidtea mediterranea mk4.033872.00  
Schmidtea mediterranea mk4.006089.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_171650 (Schistosoma mansoni), eps-15-related
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