Detailed view for Smp_137910

Basic information

TDR Targets ID: 285199
Schistosoma mansoni, tight junction protein
Source Database / ID:  GeneDB

pI: 6.3381 | Length (AA): 1286 | MW (Da): 145473 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00791   ZU5 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 95 1v5q (A) 10 108 22.00 0 1 0.336772 -0.29
6 80 4xh7 (A) 540 614 32.00 0.95 0.57 0.37052 0.02
192 239 1q3o (A) 632 679 38.00 0.12 0.92 0.514525 -0.18
419 504 2q3g (A) 0 84 27.00 0 1 0.477774 -1.45
436 841 3tsz (A) 433 802 36.00 0 1 0.444908 0.48
1080 1184 2kxs (A) 3 100 45.00 0.000000031 1 0.503848 -0.15

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129845)

Species Accession Gene Product
Brugia malayi Bm1_09575   ZU5 domain containing protein
Caenorhabditis elegans CELE_Y105E8A.26   Protein ZOO-1, isoform D
Drosophila melanogaster Dmel_CG43140   polychaetoid
Echinococcus granulosus EgrG_001029300   tight junction protein ZO 3
Echinococcus multilocularis EmuJ_001029300   tight junction protein ZO 3
Homo sapiens ENSG00000119139   tight junction protein 2
Homo sapiens ENSG00000105289   tight junction protein 3
Homo sapiens ENSG00000104067   tight junction protein 1
Loa Loa (eye worm) LOAG_00393   hypothetical protein
Mus musculus ENSMUSG00000034917   tight junction protein 3
Mus musculus ENSMUSG00000030516   tight junction protein 1
Mus musculus ENSMUSG00000024812   tight junction protein 2
Schistosoma japonicum Sjp_0106310   ko:K06097 tight junction protein 3, putative
Schistosoma japonicum Sjp_0076310   Tight junction protein ZO-1, putative
Schistosoma japonicum Sjp_0067560   IPR000906,ZU5,domain-containing
Schistosoma mansoni Smp_137910   tight junction protein

Essentiality

Smp_137910 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y105E8A.26 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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