pI: 4.8161 |
Length (AA): 426 |
MW (Da): 49250 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 289 | 2y7j (A) | 11 | 291 | 53.00 | 0 | 1 | 1.34278 | -1.3 |
15 | 419 | 3mwu (A) | 0 | 487 | 30.00 | 0 | 1 | 1.1569 | 0.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_131741)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_44555 | Protein kinase domain containing protein |
Caenorhabditis elegans | CELE_Y50D7A.3 | Protein Y50D7A.3, isoform B |
Drosophila melanogaster | Dmel_CG1830 | Phosphorylase kinase gamma |
Echinococcus granulosus | EgrG_001095600 | phosphorylase kinase gamma subunit |
Echinococcus multilocularis | EmuJ_001095600 | phosphorylase kinase gamma subunit |
Homo sapiens | ENSG00000156873 | phosphorylase kinase, gamma 2 (testis) |
Homo sapiens | ENSG00000164776 | phosphorylase kinase, gamma 1 (muscle) |
Loa Loa (eye worm) | LOAG_07421 | CAMK/PHK protein kinase |
Mus musculus | ENSMUSG00000025537 | phosphorylase kinase gamma 1 |
Mus musculus | ENSMUSG00000030815 | phosphorylase kinase, gamma 2 (testis) |
Onchocerca volvulus | OVOC8295 | Serine\/threonine kinase homolog |
Schistosoma japonicum | Sjp_0067850 | ko:K00871 phosphorylase kinase gamma subunit [EC2.7.11.19], putative |
Schistosoma japonicum | Sjp_0050020 | Conserved hypothetical protein |
Schistosoma mansoni | Smp_098840 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.031012.00 | GH28523p |
Schmidtea mediterranea | mk4.005224.02 | GH28523p |
Schmidtea mediterranea | mk4.021320.00 | GH28523p |
Schmidtea mediterranea | mk4.022188.00 | GH28523p |
Schmidtea mediterranea | mk4.002161.05 | Serine/threonine kinase |
Schmidtea mediterranea | mk4.026067.00 | GH28523p |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y50D7A.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y50D7A.3 | Caenorhabditis elegans | sterile | wormbase |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | phosphorylase kinase, gamma 1 (muscle) | Compounds | References |
Homo sapiens | phosphorylase kinase, gamma 2 (testis) | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 25.9% | 294 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 27.5% | 309 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 26.8% | 287 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 26.7% | 303 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 8 | 411 aa | 25.5% | 330 aa | Compounds | References |
Rattus norvegicus | Mitogen-activated protein kinase 1 | 358 aa | 24.6% | 305 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 23.3% | 300 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 33.9% | 168 aa | Compounds | References |
Rattus norvegicus | MAP kinase p38 alpha | 360 aa | 28.4% | 299 aa | Compounds | References |