Detailed view for Smp_001940

Basic information

TDR Targets ID: 285299
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.6541 | Length (AA): 306 | MW (Da): 35582 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05219   DREV methyltransferase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
108 180 3bt7 (A) 198 270 19.00 0.1 0.12 0.397162 0.34
108 304 5dly (A) 48 227 20.00 0 1 0.778091 0.49
113 224 1l3i (A) 26 135 19.00 0.000085 0.38 0.659613 -0.85
119 222 2p7i (A) 40 138 31.00 0.0052 0.96 0.669069 -0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131709)

Species Accession Gene Product
Brugia malayi Bm1_30675   DREV methyltransferase family protein
Caenorhabditis elegans CELE_T03G11.6   Protein T03G11.6
Dictyostelium discoideum DDB_G0281259   hypothetical protein
Drosophila melanogaster Dmel_CG5339   CG5339 gene product from transcript CG5339-RA
Echinococcus granulosus EgrG_000461000   methyltransferase9
Echinococcus multilocularis EmuJ_000461000   methyltransferase9
Homo sapiens ENSG00000197006   methyltransferase like 9
Leishmania braziliensis LbrM.30.1220   DREV methyltransferase, putative
Leishmania donovani LdBPK_301160.1   DREV methyltransferase, putative
Leishmania infantum LinJ.30.1160   DREV methyltransferase, putative
Leishmania major LmjF.30.1100   DREV methyltransferase, putative
Leishmania mexicana LmxM.29.1100   DREV methyltransferase, putative
Loa Loa (eye worm) LOAG_05975   DREV methyltransferase
Mus musculus ENSMUSG00000030876   methyltransferase like 9
Onchocerca volvulus OVOC13486  
Schistosoma japonicum Sjp_0035740   IPR007884,DREV methyltransferase,domain-containing
Schistosoma mansoni Smp_001940   hypothetical protein
Schmidtea mediterranea mk4.000993.03   Methyltransferase-like protein 9
Trypanosoma brucei gambiense Tbg972.6.2290   DREV methyltransferase, putative
Trypanosoma brucei Tb927.6.2540   DREV methyltransferase, putative
Trypanosoma congolense TcIL3000_0_55110   DREV methyltransferase, putative
Trypanosoma cruzi TcCLB.509053.170   DREV methyltransferase, putative
Trypanosoma cruzi TcCLB.509965.190   DREV methyltransferase, putative

Essentiality

Smp_001940 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.2540 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.2540 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_001940 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment