Detailed view for LmjF.35.1050

Basic information

TDR Targets ID: 28535
Leishmania major, protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.6008 | Length (AA): 489 | MW (Da): 53829 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
24 489 1omw (A) 188 667 21.00 0 1 0.85 0.74
31 334 1phk () 23 287 36.00 0 1 0.92 -0.74
25 458 5dvr (A) 49 500 28.00 0 1 1.03333 0.41
123 155 4ix3 (A) 293 325 42.00 0.033 0.81 0.557385 -0.07
135 268 2qkw (B) 151 238 49.00 0.000088 0.51 0.0789286 1.08
255 359 2wnt (A) 598 700 30.00 0 1 0.624124 -0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_165260)

Species Accession Gene Product
Leishmania braziliensis LbrM.27.0360   protein kinase, putative
Leishmania donovani LdBPK_351070.1   protein kinase, putative
Leishmania infantum LinJ.35.1070   protein kinase, putative
Leishmania major LmjF.35.1050   protein kinase, putative
Leishmania mexicana LmxM.34.1050   protein kinase, putative
Trypanosoma cruzi TcCLB.503599.10   calcium/calmodulin-dependent protein kinase, putative
Trypanosoma cruzi TcCLB.509409.10   calcium/calmodulin-dependent protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 23.1% 295 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.3% 284 aa Compounds References
Patiria pectinifera Cdc2 300 aa 25.8% 326 aa Compounds References
Bos taurus Glycogen synthase kinase-3 beta splice variant X1 419 aa 25.2% 365 aa Compounds References
Sus scrofa Glycogen synthase kinase-3 483 aa 24.7% 417 aa Compounds References
Xenopus laevis Aurora kinase B-B 368 aa 27.3% 319 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 24.7% 332 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.8% 345 aa Compounds References
Rattus norvegicus Glycogen synthase kinase-3 beta 420 aa 24.9% 365 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 24.2% 331 aa Compounds References
Zea mays Casein kinase II alpha 332 aa 20.4% 285 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 21.2% 339 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 24.4% 328 aa Compounds References
Sus scrofa Glycogen synthase kinase 3 beta 420 aa 25.8% 364 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 27.2% 202 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 27.4% 321 aa Compounds References
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 23.5% 328 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 26.1% 348 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 25.3% 297 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0059 1 1
0.0069 0.3067 1
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0007 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0029 0.5 0.5
0.0092 1 0.5
0.0011 1 0.5
0.0008 0.5 0.5
0.0098 0.3242 0.2614
0.0039 0.9485 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0061 0.6883 0.5304
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5
0.0032 0.5 0.5
0.0093 0.8828 0
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 1
0.0064 0.3377 0
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.2543
0.0007 0.5 0.5
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.1050 (Leishmania major), protein kinase, putative
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