pI: 9.6856 |
Length (AA): 338 |
MW (Da): 37526 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
76 | 165 | 1vcs (A) | 11 | 97 | 24.00 | 0.000082 | 0.99 | 0.64 | -1.31 |
5 | 145 | 4tql (A) | 35 | 176 | 8.00 | 0.019 | 0 | 0.47936 | -0.11 |
55 | 155 | 2qyw (A) | 5 | 92 | 22.00 | 0 | 0.28 | 0.467817 | -0.87 |
56 | 155 | 1vcs (A) | 2 | 87 | 22.00 | 0.69 | 0.81 | 0.472058 | -0.64 |
116 | 187 | 2i1j (A) | 307 | 455 | 33.00 | 0.95 | 0.03 | 0.486018 | 0.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127758)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G26670 | vesicle transport v-SNARE 12 |
Arabidopsis thaliana | AT5G39510 | vesicle transport v-SNARE 11 |
Candida albicans | CaO19.7970 | v-SNARE |
Candida albicans | CaO19.337 | similar to v-SNARE/docking protein |
Caenorhabditis elegans | CELE_Y57G11C.4 | Protein VTI-1 |
Cryptosporidium hominis | Chro.30027 | hypothetical protein |
Cryptosporidium parvum | cgd3_180 | domain KOG1666, V-SNARE (intracellular trafficking, secretion, and vesicular transport) |
Dictyostelium discoideum | DDB_G0292974 | v-SNARE family protein |
Drosophila melanogaster | Dmel_CG3279 | VTI1 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000477100 | vesicle transport through interaction with |
Entamoeba histolytica | EHI_068480 | hypothetical protein |
Entamoeba histolytica | EHI_117250 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_000477100 | vesicle transport through interaction with |
Homo sapiens | ENSG00000151532 | vesicle transport through interaction with t-SNAREs 1A |
Homo sapiens | 10490 | vesicle transport through interaction with t-SNAREs 1B |
Leishmania braziliensis | LbrM.23.1650 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_231800.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.23.1800 | hypothetical protein, conserved |
Leishmania major | LmjF.23.1750 | Qb-SNARE protein, putative |
Leishmania mexicana | LmxM.23.1750 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_02464 | hypothetical protein |
Mus musculus | ENSMUSG00000024983 | vesicle transport through interaction with t-SNAREs 1A |
Mus musculus | ENSMUSG00000021124 | vesicle transport through interaction with t-SNAREs 1B |
Neospora caninum | NCLIV_067830 | hypothetical protein |
Neospora caninum | NCLIV_017380 | Vesicle transport v-SNARE domain-containing protein, related |
Oryza sativa | 9271687 | Os01g0560350 |
Oryza sativa | 4324687 | Os01g0560200 |
Oryza sativa | 4327678 | Os01g0707300 |
Saccharomyces cerevisiae | YMR197C | Vti1p |
Schistosoma japonicum | Sjp_0304890 | ko:K08493 vesicle transport through interaction with t-SNAREs 1, putative |
Schistosoma mansoni | Smp_068480 | vesicle transport V-snare protein vti1a |
Schmidtea mediterranea | mk4.000578.04 | Putative vesicle transport V-snare protein vti1a |
Trypanosoma cruzi | TcCLB.509767.210 | vesicle transport v-SNARE 11, putative |
Trypanosoma cruzi | TcCLB.507645.20 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_242080 | hypothetical protein |
Toxoplasma gondii | TGME49_278160 | vesicle transport v-snare protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YMR197C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_278160 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_242080 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.