Detailed view for Smp_127340

Basic information

TDR Targets ID: 285671
Schistosoma mansoni, NADH-ubiquinone oxidoreductase
Source Database / ID:  GeneDB

pI: 8.1897 | Length (AA): 538 | MW (Da): 61775 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00346   Respiratory-chain NADH dehydrogenase, 49 Kd subunit
PF12352   Snare region anchored in the vesicle membrane C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0016651   oxidoreductase activity, acting on NADH or NADPH  
GO:0016020   membrane  
GO:0051287   NAD binding  
GO:0048038   quinone binding  
GO:0009055   electron carrier activity  
GO:0055114   oxidation reduction  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
254 307 1vdc (A) 257 308 47.00 0.65 0.79 0.450272 0.54
323 498 3r6n (A) 195 368 13.00 0 0.12 0.485738 -0.7
323 429 1fio (A) 50 157 12.00 0 0.15 0.371185 -0.77
323 486 6gy7 (C) 60 258 20.00 0 0.79 0.407433 0.36
324 503 3zqe (A) 132 317 13.00 0 0.37 0.405172 0.03
405 518 6c8z (A) 175 291 31.00 0.019 0.3 0.372796 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127839)

Species Accession Gene Product
Arabidopsis thaliana ArthMp043   NADH dehydrogenase subunit 7
Arabidopsis thaliana ArthCp080   NADH dehydrogenase 49 kDa subunit
Brugia malayi Bm1_38090   Probable NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrialprecursor
Brugia malayi Bm1_25145   NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial
Candida albicans CaO19.6531   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUCM subunit and N. crassa and
Candida albicans CaO19.13884   potential mitochondrial NADH-Ubiquinone Oxidoreductase Complex I subunit similar to Y.lipolytica NUCM subunit and N. crassa and
Candida albicans CaO19_6531   hypothetical protein
Caenorhabditis elegans CELE_T26A5.3   Protein NDUF-2.2
Caenorhabditis elegans CELE_K09A9.5   Protein GAS-1
Dictyostelium discoideum DidioMp18   NADH dehydrogenase subunit 7
Drosophila melanogaster Dmel_CG1970   CG1970 gene product from transcript CG1970-RB
Drosophila melanogaster Dmel_CG11913   CG11913 gene product from transcript CG11913-RB
Escherichia coli b2286   NADH:ubiquinone oxidoreductase, fused CD subunit
Echinococcus granulosus EgrG_000951700   Golgi SNAP receptor complex
Echinococcus granulosus EgrG_000720300   NADH dehydrogenase ubiquinone Fe S protein 2
Echinococcus multilocularis EmuJ_000951700   Golgi SNAP receptor complex
Echinococcus multilocularis EmuJ_000720300   NADH dehydrogenase (ubiquinone) Fe S protein 2
Homo sapiens ENSG00000158864   NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Loa Loa (eye worm) LOAG_05466   hypothetical protein
Loa Loa (eye worm) LOAG_01369   hypothetical protein
Mus musculus ENSMUSG00000013593   NADH dehydrogenase (ubiquinone) Fe-S protein 2
Mycobacterium tuberculosis Rv3148   Probable NADH dehydrogenase I (chain D) NuoD (NADH-ubiquinone oxidoreductase chain D)
Mycobacterium ulcerans MUL_2462   NADH dehydrogenase subunit D
Oryza sativa 6450198   NADH dehydrogenase subunit 7
Oryza sativa 3131489   NADH dehydrogenase 49 kDa subunit
Oryza sativa 3131485   ORF56
Schistosoma japonicum Sjp_0205360   ko:K08496 golgi SNAP receptor complex member 2 (Membrin), putative
Schistosoma japonicum Sjp_0205370   ko:K03935 NADH dehydrogenase (ubiquinone) Fe-S protein 2, putative
Schistosoma mansoni Smp_127340   NADH-ubiquinone oxidoreductase
Schmidtea mediterranea mk4.000370.01   NADH dehydrogenase
Schmidtea mediterranea mk4.000370.00   NADH dehydrogenase
Schmidtea mediterranea mk4.070622.02   NADH dehydrogenase
Wolbachia endosymbiont of Brugia malayi Wbm0125   NADH dehydrogenase subunit D

Essentiality

Smp_127340 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K09A9.5 Caenorhabditis elegans larval arrest wormbase
CELE_K09A9.5 Caenorhabditis elegans sterile wormbase
CELE_T26A5.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T26A5.3 Caenorhabditis elegans larval arrest wormbase
CELE_T26A5.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_127340 (Schistosoma mansoni), NADH-ubiquinone oxidoreductase
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