pI: 8.4193 |
Length (AA): 214 |
MW (Da): 24779 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 156 | 2nut (C) | 1 | 157 | 53.00 | 0 | 1 | 1.28827 | -0.89 |
132 | 187 | 3b5n (A) | 27 | 82 | 29.00 | 0 | 0.03 | 0.643982 | -0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128390)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G52270 | SNARE-like superfamily protein |
Arabidopsis thaliana | AT1G11890 | vesicle transport protein SEC22 |
Babesia bovis | BBOV_II004640 | vesicle transport protein, putative |
Brugia malayi | Bm1_04820 | vesicle trafficking protein SEC22b |
Caenorhabditis elegans | CELE_F55A4.1 | Protein SEC-22 |
Cryptosporidium hominis | Chro.10214 | vesicle transport protein |
Cryptosporidium parvum | cgd1_1890 | vesicle transport protein, putative |
Dictyostelium discoideum | DDB_G0269942 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7359 | Sec22 ortholog (S. cerevisiae) |
Echinococcus granulosus | EgrG_000253300 | vesicle trafficking protein SEC22b |
Echinococcus multilocularis | EmuJ_000253300 | vesicle trafficking protein SEC22b |
Giardia lamblia | GL50803_9489 | V-SNARE |
Loa Loa (eye worm) | LOAG_01117 | vesicle trafficking protein SEC22b |
Mus musculus | 20333 | SEC22 vesicle trafficking protein homolog B (S. cerevisiae) |
Neospora caninum | NCLIV_036540 | vesicle trafficking protein, putative |
Oryza sativa | 4334384 | Os03g0791500 |
Oryza sativa | 9271327 | Os06g0198800 |
Plasmodium berghei | PBANKA_1218400 | protein transport protein SEC22, putative |
Plasmodium falciparum | PF3D7_0320100 | protein transport protein SEC22 |
Plasmodium knowlesi | PKNH_0821100 | protein transport protein SEC22, putative |
Plasmodium vivax | PVX_095230 | vesicle transport protein Sec22, putative |
Plasmodium yoelii | PY01819 | hypothetical protein |
Plasmodium yoelii | PY01820 | hypothetical protein |
Saccharomyces cerevisiae | YLR268W | Sec22p |
Schistosoma japonicum | Sjp_0213430 | ko:K08517 vesicle transport protein SEC22, putative |
Schistosoma mansoni | Smp_035300.2 | snare protein sec22 |
Schistosoma mansoni | Smp_035300.1 | snare protein sec22 |
Schmidtea mediterranea | mk4.002757.02 | Putative snare protein sec22 |
Schmidtea mediterranea | mk4.001859.03 | |
Trypanosoma brucei gambiense | Tbg972.10.15000 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.12450 | SNARE domain-containing protein, putative |
Trypanosoma cruzi | TcCLB.507625.183 | SNARE domain-containing protein, putative |
Trypanosoma cruzi | TcCLB.509741.40 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_270070 | synaptobrevin family protein |
Theileria parva | TP02_0290 | vesicle transport protein, putative |
Trichomonas vaginalis | TVAG_381070 | snare proteins, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.12450 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.12450 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.12450 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.12450 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1218400 | Plasmodium berghei | Essential | plasmo |
TGME49_270070 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | MHC class II | 127 aa | 24.6% | 114 aa | Compounds | References |