Detailed view for Smp_166460

Basic information

TDR Targets ID: 285788
Schistosoma mansoni, oligomeric golgi complex component
Source Database / ID:  GeneDB

pI: 5.4265 | Length (AA): 669 | MW (Da): 75894 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08318   COG4 transport protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 669 2x19 (B) 312 949 11.00 0 0.93 0.987231 0.45
509 669 3hr0 (A) 536 698 27.00 0 0.92 0.609058 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129076)

Species Accession Gene Product
Arabidopsis thaliana AT4G01400   hypothetical protein
Brugia malayi Bm1_01690   Conserved oligomeric Golgi complex component 4, putative
Candida albicans CaO19.6880   similar to S. cerevisiae COG4 (YPR105C) intra-Golgi transport complex subunit
Candida albicans CaO19.14169   similar to S. cerevisiae COG4 (YPR105C) intra-Golgi transport complex component
Caenorhabditis elegans CELE_Y51H7C.6   Protein COGC-4, isoform A
Cryptosporidium parvum cgd7_3750   oligomeric golgi complex protein 4
Dictyostelium discoideum DDB_G0267960   oligomeric Golgi complex component
Drosophila melanogaster Dmel_CG7456   CG7456 gene product from transcript CG7456-RA
Echinococcus granulosus EgrG_000481000   oligomeric Golgi complex subunit
Echinococcus multilocularis EmuJ_000481000   oligomeric Golgi complex subunit
Homo sapiens ENSG00000103051   component of oligomeric golgi complex 4
Loa Loa (eye worm) LOAG_00872   hypothetical protein
Mus musculus ENSMUSG00000031753   component of oligomeric golgi complex 4
Oryza sativa 9267023   Os02g0456000
Saccharomyces cerevisiae YPR105C   Cog4p
Schistosoma japonicum Sjp_0010360   Conserved oligomeric Golgi complex component 4, putative
Schistosoma japonicum Sjp_0010340   Conserved oligomeric Golgi complex component 4, putative
Schistosoma mansoni Smp_192100   hypothetical protein
Schistosoma mansoni Smp_118480   hypothetical protein
Schistosoma mansoni Smp_166460   oligomeric golgi complex component
Schistosoma mansoni Smp_180640   hypothetical protein
Schistosoma mansoni Smp_121530   hypothetical protein
Schistosoma mansoni Smp_080070   hypothetical protein
Schmidtea mediterranea mk4.001556.10  
Schmidtea mediterranea mk4.001556.07   Conserved oligomeric Golgi complex subunit 4
Schmidtea mediterranea mk4.001556.08   Conserved oligomeric Golgi complex subunit 4
Trichomonas vaginalis TVAG_476340   hypothetical protein

Essentiality

Smp_166460 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y51H7C.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y51H7C.6 Caenorhabditis elegans larval arrest wormbase
CELE_Y51H7C.6 Caenorhabditis elegans larval lethal wormbase
CELE_Y51H7C.6 Caenorhabditis elegans slow growth wormbase
CELE_Y51H7C.6 Caenorhabditis elegans sterile wormbase
YPR105C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_166460 (Schistosoma mansoni), oligomeric golgi complex component
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