pI: 5.6244 |
Length (AA): 129 |
MW (Da): 15074 |
Paralog Number:
160
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
24 | 110 | 1l9m (A) | 539 | 616 | 33.00 | 0.31 | 0.13 | 0.699419 | 1.7 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126814)
Species | Accession | Gene Product |
---|---|---|
Echinococcus granulosus | EgrG_000961800 | nuclear pore complex protein Nup107 |
Echinococcus granulosus | EgrG_001054000 | fibrillin 2 |
Echinococcus granulosus | EgrG_000264700 | hypothetical protein |
Echinococcus granulosus | EgrG_000248900 | gag pol polyprotein |
Echinococcus granulosus | EgrG_000943300 | G patch domain containing 1 |
Echinococcus granulosus | EgrG_000466300 | oligopeptidase |
Echinococcus granulosus | EgrG_000616800 | ubiquitin conjugating enzyme |
Echinococcus granulosus | EgrG_001087700 | 60s ribosomal protein l7 |
Echinococcus granulosus | EgrG_000717100 | myelin proteolipid |
Echinococcus granulosus | EgrG_000961700 | Ubiquitin associated translation elongation factor EF1B |
Echinococcus multilocularis | EmuJ_000943300 | G patch domain containing 1 |
Echinococcus multilocularis | EmuJ_000264700 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000466300 | oligopeptidase |
Echinococcus multilocularis | EmuJ_001087700 | 60s ribosomal protein l7 |
Echinococcus multilocularis | EmuJ_000248900 | gag pol polyprotein |
Echinococcus multilocularis | EmuJ_000717100 | myelin proteolipid |
Echinococcus multilocularis | EmuJ_001054000 | fibrillin 2 |
Echinococcus multilocularis | EmuJ_000961800 | nuclear pore complex protein Nup107 |
Echinococcus multilocularis | EmuJ_000616800 | ubiquitin conjugating enzyme |
Schistosoma japonicum | Sjp_0112000 | IPR000449,Ubiquitin-associated;IPR009060,UBA-like,domain-containing |
Schistosoma japonicum | Sjp_0219350 | IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0107140 | IPR006209,EGF-like;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR013032,EGF-like region,domain-containing |
Schistosoma japonicum | Sjp_0053130 | Latent-transforming growth factor beta-binding protein, isoform 1L precursor, putative |
Schistosoma japonicum | Sjp_0079620 | ko:K10704 ubiquitin-conjugating enzyme E2 variant, putative |
Schistosoma japonicum | Sjp_0002790 | Transposon Ty3-G Gag-Pol polyprotein, putative |
Schistosoma japonicum | Sjp_0067380 | Pol polyprotein [Contains: Reverse transcriptase/ribonuclease H, putative |
Schistosoma japonicum | Sjp_0022040 | IPR001567,Peptidase M3A and M3B, thimet/oligopeptidase F,domain-containing |
Schistosoma japonicum | Sjp_0041960 | IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0028390 | expressed protein |
Schistosoma japonicum | Sjp_0109290 | hypothetical protein |
Schistosoma japonicum | Sjp_0304250 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0077680 | 60S ribosomal protein L7, putative |
Schistosoma japonicum | Sjp_0096990 | expressed protein |
Schistosoma japonicum | Sjp_0053140 | Nuclear pore complex protein Nup107, putative |
Schistosoma japonicum | Sjp_0116540 | IPR001584,Integrase, catalytic region;IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0305910 | IPR013032,EGF-like region;IPR013111,EGF, extracellular;IPR006210,EGF,domain-containing |
Schistosoma japonicum | Sjp_0209680 | expressed protein |
Schistosoma japonicum | Sjp_0022670 | IPR012337,Polynucleotidyl transferase, Ribonuclease H fold,domain-containing |
Schistosoma japonicum | Sjp_0057410 | ko:K09555 BCL2-associated athanogene 1, putative |
Schistosoma japonicum | Sjp_0076900 | hypothetical protein |
Schistosoma japonicum | Sjp_0089180 | G patch domain-containing protein 1, putative |
Schistosoma japonicum | Sjp_0008720 | Retrovirus-related Pol polyprotein from transposon opus [Includes: Protease, putative |
Schistosoma japonicum | Sjp_0311600 | Nuclear pore complex protein Nup107, putative |
Schistosoma japonicum | Sjp_0032020 | IPR006209,EGF-like;IPR013032,EGF-like region,domain-containing |
Schistosoma japonicum | Sjp_0037060 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0219230 | similar to Retrotransposable element Tf2 155 kDa protein type 3, putative |
Schistosoma mansoni | Smp_114740 | hypothetical protein |
Schistosoma mansoni | Smp_192540 | hypothetical protein |
Schistosoma mansoni | Smp_157030 | hypothetical protein |
Schistosoma mansoni | Smp_193940 | hypothetical protein |
Schistosoma mansoni | Smp_194500 | hypothetical protein |
Schistosoma mansoni | Smp_183030 | hypothetical protein |
Schistosoma mansoni | Smp_100790 | hypothetical protein |
Schistosoma mansoni | Smp_190300 | hypothetical protein |
Schistosoma mansoni | Smp_124790 | hypothetical protein |
Schistosoma mansoni | Smp_124550 | hypothetical protein |
Schistosoma mansoni | Smp_138820 | hypothetical protein |
Schistosoma mansoni | Smp_122190 | hypothetical protein |
Schistosoma mansoni | Smp_135810 | hypothetical protein |
Schistosoma mansoni | Smp_164460 | hypothetical protein |
Schistosoma mansoni | Smp_124400 | hypothetical protein |
Schistosoma mansoni | Smp_132960 | hypothetical protein |
Schistosoma mansoni | Smp_175380 | hypothetical protein |
Schistosoma mansoni | Smp_132570 | choline/ethanolamine kinase |
Schistosoma mansoni | Smp_190450 | hypothetical protein |
Schistosoma mansoni | Smp_122320 | hypothetical protein |
Schistosoma mansoni | Smp_049790 | hypothetical protein |
Schistosoma mansoni | Smp_107670 | hypothetical protein |
Schistosoma mansoni | Smp_061930 | hypothetical protein |
Schistosoma mansoni | Smp_189480 | hypothetical protein |
Schistosoma mansoni | Smp_001085 | gag-pol protein |
Schistosoma mansoni | Smp_130150 | hypothetical protein |
Schistosoma mansoni | Smp_127260 | hypothetical protein |
Schistosoma mansoni | Smp_117360 | hypothetical protein |
Schistosoma mansoni | Smp_163390 | hypothetical protein |
Schistosoma mansoni | Smp_177070 | hypothetical protein |
Schistosoma mansoni | Smp_190710 | hypothetical protein |
Schistosoma mansoni | Smp_127820 | hypothetical protein |
Schistosoma mansoni | Smp_137290 | hypothetical protein |
Schistosoma mansoni | Smp_135410 | hypothetical protein |
Schistosoma mansoni | Smp_174560 | hypothetical protein |
Schistosoma mansoni | Smp_130720 | hypothetical protein |
Schistosoma mansoni | Smp_189980 | hypothetical protein |
Schistosoma mansoni | Smp_175350 | hypothetical protein |
Schistosoma mansoni | Smp_185870 | hypothetical protein |
Schistosoma mansoni | Smp_132110 | hypothetical protein |
Schistosoma mansoni | Smp_173950 | hypothetical protein |
Schistosoma mansoni | Smp_165450 | hypothetical protein |
Schistosoma mansoni | Smp_184840 | hypothetical protein |
Schistosoma mansoni | Smp_166810 | hypothetical protein |
Schistosoma mansoni | Smp_049800 | hypothetical protein |
Schistosoma mansoni | Smp_162950 | hypothetical protein |
Schistosoma mansoni | Smp_118790 | hypothetical protein |
Schistosoma mansoni | Smp_132650 | hypothetical protein |
Schistosoma mansoni | Smp_150000 | hypothetical protein |
Schistosoma mansoni | Smp_004540 | hypothetical protein |
Schistosoma mansoni | Smp_131920 | hypothetical protein |
Schistosoma mansoni | Smp_107430 | hypothetical protein |
Schistosoma mansoni | Smp_001090 | nuclear pore complex protein |
Schistosoma mansoni | Smp_131140 | hypothetical protein |
Schistosoma mansoni | Smp_141870 | hypothetical protein |
Schistosoma mansoni | Smp_110650 | hypothetical protein |
Schistosoma mansoni | Smp_126570 | hypothetical protein |
Schistosoma mansoni | Smp_173310 | hypothetical protein |
Schistosoma mansoni | Smp_189260 | hypothetical protein |
Schistosoma mansoni | Smp_190560 | hypothetical protein |
Schistosoma mansoni | Smp_148710 | hypothetical protein |
Schistosoma mansoni | Smp_115930 | hypothetical protein |
Schistosoma mansoni | Smp_154310 | family A2 unassigned peptidase (A02 family) |
Schistosoma mansoni | Smp_155710 | hypothetical protein |
Schistosoma mansoni | Smp_082500 | hypothetical protein |
Schistosoma mansoni | Smp_116170 | hypothetical protein |
Schistosoma mansoni | Smp_190850 | hypothetical protein |
Schistosoma mansoni | Smp_070720 | hypothetical protein |
Schistosoma mansoni | Smp_155660 | hypothetical protein |
Schistosoma mansoni | Smp_188760 | hypothetical protein |
Schistosoma mansoni | Smp_147130 | hypothetical protein |
Schistosoma mansoni | Smp_188770 | hypothetical protein |
Schistosoma mansoni | Smp_167720 | hypothetical protein |
Schistosoma mansoni | Smp_125830 | hypothetical protein |
Schistosoma mansoni | Smp_191060 | hypothetical protein |
Schistosoma mansoni | Smp_160720 | hypothetical protein |
Schistosoma mansoni | Smp_190570 | hypothetical protein |
Schistosoma mansoni | Smp_097670 | hypothetical protein |
Schistosoma mansoni | Smp_172230 | hypothetical protein |
Schistosoma mansoni | Smp_189170 | hypothetical protein |
Schistosoma mansoni | Smp_110800 | hypothetical protein |
Schistosoma mansoni | Smp_004230 | hypothetical protein |
Schistosoma mansoni | Smp_091070 | hypothetical protein |
Schistosoma mansoni | Smp_095200 | hypothetical protein |
Schistosoma mansoni | Smp_190540 | hypothetical protein |
Schistosoma mansoni | Smp_166950 | hypothetical protein |
Schistosoma mansoni | Smp_173140 | subfamily M3A non-peptidase homologue (M03 family) |
Schistosoma mansoni | Smp_116840 | hypothetical protein |
Schistosoma mansoni | Smp_160990 | hypothetical protein |
Schistosoma mansoni | Smp_140280 | hypothetical protein |
Schistosoma mansoni | Smp_181600 | hypothetical protein |
Schistosoma mansoni | Smp_166600 | ubiquitin conjugating enzyme |
Schistosoma mansoni | Smp_175880 | hypothetical protein |
Schistosoma mansoni | Smp_159820 | hypothetical protein |
Schistosoma mansoni | Smp_174460 | hypothetical protein |
Schistosoma mansoni | Smp_144230 | hypothetical protein |
Schistosoma mansoni | Smp_170190 | hypothetical protein |
Schistosoma mansoni | Smp_164870 | hypothetical protein |
Schistosoma mansoni | Smp_072670 | hypothetical protein |
Schistosoma mansoni | Smp_190840 | hypothetical protein |
Schistosoma mansoni | Smp_124560 | hypothetical protein |
Schistosoma mansoni | Smp_189710 | hypothetical protein |
Schistosoma mansoni | Smp_193950 | hypothetical protein |
Schistosoma mansoni | Smp_161690 | hypothetical protein |
Schistosoma mansoni | Smp_159500 | hypothetical protein |
Schistosoma mansoni | Smp_151170 | hypothetical protein |
Schistosoma mansoni | Smp_138460 | myelin proteolipid-related |
Schistosoma mansoni | Smp_082460 | hypothetical protein |
Schistosoma mansoni | Smp_175080 | hypothetical protein |
Schistosoma mansoni | Smp_015160 | hypothetical protein |
Schistosoma mansoni | Smp_190310 | hypothetical protein |
Schistosoma mansoni | Smp_170000 | hypothetical protein |
Schistosoma mansoni | Smp_139870 | hypothetical protein |
Schistosoma mansoni | Smp_145340 | hypothetical protein |
Schistosoma mansoni | Smp_167560 | hypothetical protein |
Schistosoma mansoni | Smp_164980 | hypothetical protein |
Schistosoma mansoni | Smp_182800 | hypothetical protein |
Schistosoma mansoni | Smp_079720 | hypothetical protein |
Schistosoma mansoni | Smp_174330 | hypothetical protein |
Schistosoma mansoni | Smp_190760 | hypothetical protein |
Schistosoma mansoni | Smp_192910 | hypothetical protein |
Schistosoma mansoni | Smp_001110 | hypothetical protein |
Schistosoma mansoni | Smp_138650 | hypothetical protein |
Schistosoma mansoni | Smp_160980 | hypothetical protein |
Schistosoma mansoni | Smp_123400 | hypothetical protein |
Schistosoma mansoni | Smp_131750 | hypothetical protein |
Schistosoma mansoni | Smp_192090 | hypothetical protein |
Schistosoma mansoni | Smp_192230 | hypothetical protein |
Schistosoma mansoni | Smp_169810 | hypothetical protein |
Schistosoma mansoni | Smp_173500 | hypothetical protein |
Schistosoma mansoni | Smp_132360 | hypothetical protein |
Schistosoma mansoni | Smp_149190 | hypothetical protein |
Schistosoma mansoni | Smp_163370 | hypothetical protein |
Schistosoma mansoni | Smp_194440 | hypothetical protein |
Schistosoma mansoni | Smp_174600 | hypothetical protein |
Schistosoma mansoni | Smp_004530 | hypothetical protein |
Schistosoma mansoni | Smp_184420 | hypothetical protein |
Schistosoma mansoni | Smp_001100 | hypothetical protein |
Schistosoma mansoni | Smp_189250 | hypothetical protein |
Schistosoma mansoni | Smp_071290 | hypothetical protein |
Schistosoma mansoni | Smp_184980 | hypothetical protein |
Schistosoma mansoni | Smp_036260 | hypothetical protein |
Schistosoma mansoni | Smp_192010 | hypothetical protein |
Schistosoma mansoni | Smp_177750 | hypothetical protein |
Schistosoma mansoni | Smp_183420 | hypothetical protein |
Schistosoma mansoni | Smp_184850 | hypothetical protein |
Schistosoma mansoni | Smp_155830 | solute carrier family 35 member C1 |
Schistosoma mansoni | Smp_178530 | hypothetical protein |
Schistosoma mansoni | Smp_191700 | hypothetical protein |
Schistosoma mansoni | Smp_193130 | hypothetical protein |
Schistosoma mansoni | Smp_136090 | 60S ribosomal protein L7 |
Schistosoma mansoni | Smp_072440 | hypothetical protein |
Schistosoma mansoni | Smp_192880 | hypothetical protein |
Schistosoma mansoni | Smp_159610 | hypothetical protein |
Schistosoma mansoni | Smp_192510 | hypothetical protein |
Schistosoma mansoni | Smp_179640 | hypothetical protein |
Schistosoma mansoni | Smp_177660 | hypothetical protein |
Schistosoma mansoni | Smp_144150 | hypothetical protein |
Schistosoma mansoni | Smp_183300 | hypothetical protein |
Schistosoma mansoni | Smp_183310 | hypothetical protein |
Schistosoma mansoni | Smp_188550 | hypothetical protein |
Schmidtea mediterranea | mk4.013889.01 | |
Schmidtea mediterranea | mk4.001397.04 | |
Schmidtea mediterranea | mk4.018883.00 | |
Schmidtea mediterranea | mk4.000323.12 | |
Schmidtea mediterranea | mk4.001763.04 | |
Schmidtea mediterranea | mk4.022574.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.