Detailed view for Smp_158190

Basic information

TDR Targets ID: 286388
Schistosoma mansoni, organic solute transporter
Source Database / ID:  GeneDB

pI: 6.1485 | Length (AA): 414 | MW (Da): 46756 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03619   Organic solute transporter Ostalpha

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
32 84 5u8o (A) 70 128 34.00 0.67 0.37 0.254519 1.21
346 414 1iab (A) 106 173 15.00 0 0.01 0.310467 -0.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126850)

Species Accession Gene Product
Arabidopsis thaliana AT5G26740   hypothetical protein
Arabidopsis thaliana AT3G05940   hypothetical protein
Arabidopsis thaliana AT1G77220   hypothetical protein
Babesia bovis BBOV_II005420   hypothetical protein
Brugia malayi Bm1_40780   MAP kinase activating protein C22orf5
Candida albicans CaO19.6981   potential membrane protein similar to S. cerevisiae YKR051W
Caenorhabditis elegans CELE_F40E10.6   Protein F40E10.6
Cryptosporidium hominis Chro.20450   hypothetical protein
Cryptosporidium parvum cgd2_4200   hypothetical protein
Dictyostelium discoideum DDB_G0291287   transmembrane protein 184D
Dictyostelium discoideum DDB_G0279555   transmembrane protein 184C
Dictyostelium discoideum DDB_G0304961   transmembrane protein 184E
Dictyostelium discoideum DDB_G0276041   transmembrane protein 184B
Dictyostelium discoideum DDB_G0284525   transmembrane protein 184A
Drosophila melanogaster Dmel_CG5850   CG5850 gene product from transcript CG5850-RD
Drosophila melanogaster Dmel_CG12004   CG12004 gene product from transcript CG12004-RD
Echinococcus granulosus EgrG_000744500   transmembrane protein 184c
Echinococcus granulosus EgrG_000090300   transmembrane protein 184A
Entamoeba histolytica EHI_153730   hypothetical protein
Echinococcus multilocularis EmuJ_000090300   transmembrane protein 184A
Echinococcus multilocularis EmuJ_000744500   transmembrane protein 184c
Homo sapiens 55751   transmembrane protein 184C
Homo sapiens ENSG00000164855   transmembrane protein 184A
Homo sapiens ENSG00000198792   transmembrane protein 184B
Leishmania braziliensis LbrM.11.0940   hypothetical protein, conserved
Leishmania braziliensis LbrM.35.7050   hypothetical protein, conserved,f2o10.10 protein-like protein
Leishmania donovani LdBPK_367000.1   hypothetical protein, conserved
Leishmania donovani LdBPK_111190.1   Organic solute transporter Ostalpha, putative
Leishmania infantum LinJ.11.1190   hypothetical protein, conserved
Leishmania infantum LinJ.36.7000   hypothetical protein, conserved,f2o10.10 protein-like protein
Leishmania major LmjF.36.6690   hypothetical protein, conserved,f2o10.10 protein-like protein
Leishmania major LmjF.11.1200   hypothetical protein, conserved
Leishmania mexicana LmxM.11.1200   hypothetical protein, conserved
Leishmania mexicana LmxM.36.6690   hypothetical protein, conserved,f2o10.10 protein-like protein
Loa Loa (eye worm) LOAG_02862   MAP kinase activating protein C22orf5
Mus musculus ENSMUSG00000031617   transmembrane protein 184C
Mus musculus ENSMUSG00000036687   transmembrane protein 184a
Mus musculus ENSMUSG00000009035   transmembrane protein 184b
Neospora caninum NCLIV_043640   Transmembrane protein 184A, related
Neospora caninum NCLIV_034350   ACR261Cp, related
Oryza sativa 4342119   Os06g0726600
Oryza sativa 4339325   Os05g0516900
Oryza sativa 4330269   Os02g0670000
Oryza sativa 4342821   Os07g0244300
Onchocerca volvulus OVOC5337  
Saccharomyces cerevisiae YKR051W   hypothetical protein
Schistosoma japonicum Sjp_0030840   Transmembrane protein 184B, putative
Schistosoma mansoni Smp_126920   organic solute transporter
Schistosoma mansoni Smp_158190   organic solute transporter
Schmidtea mediterranea mk4.003246.04   Putative organic solute transporter
Schmidtea mediterranea mk4.000924.03   Transmembrane protein 184C
Schmidtea mediterranea mk4.000843.13   Putative organic solute transporter
Trypanosoma brucei gambiense Tbg972.10.9750   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.7970   Organic solute transporter Ostalpha, putative
Trypanosoma congolense TcIL3000_10_6840   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506297.340   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508041.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506247.290   Organic solute transporter Ostalpha, putative
Toxoplasma gondii TGME49_210380   hypothetical protein
Toxoplasma gondii TGME49_273200   hypothetical protein
Theileria parva TP02_0493   hypothetical protein, conserved

Essentiality

Smp_158190 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.7970 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.7970 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.7970 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.7970 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_210380 Toxoplasma gondii Probably non-essential sidik
TGME49_273200 Toxoplasma gondii Probably non-essential sidik
TGME49_210380 Toxoplasma gondii Essentiality uncertain sidik
TGME49_273200 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_158190 (Schistosoma mansoni), organic solute transporter
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