Detailed view for Smp_158840

Basic information

TDR Targets ID: 286410
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 8.7992 | Length (AA): 595 | MW (Da): 68486 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06862   Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 290 2oxc (A) 64 263 19.00 0 0.32 0.268504 0.35
342 400 1d9x (A) 441 499 12.00 0.62 0 0.25116 -0.41
466 589 2hjv (A) 236 355 14.00 0.0000000028 0.95 0.468403 -0.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128175)

Species Accession Gene Product
Arabidopsis thaliana AT1G17690   hypothetical protein
Babesia bovis BBOV_IV006620   conserved hypothetical protein
Brugia malayi Bm1_23940   Hypothetical 84.0 kDa protein in SGA1-KTR7 intergenic region
Candida albicans CaO19.9407   similar to S. cerevisiae YIL091C
Candida albicans CaO19.1849   similar to S. cerevisiae YIL091C
Caenorhabditis elegans CELE_Y41C4A.9   Protein Y41C4A.9
Cryptosporidium hominis Chro.70038   hypothetical protein
Cryptosporidium parvum cgd7_250   conserved protein
Dictyostelium discoideum DDB_G0289235   hypothetical protein
Drosophila melanogaster Dmel_CG3735   CG3735 gene product from transcript CG3735-RB
Echinococcus granulosus EgrG_000837700   digestive organ expansion factor
Entamoeba histolytica EHI_177370   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000837700   digestive organ expansion factor
Giardia lamblia GL50803_6211   Protein required for cell viability
Homo sapiens ENSG00000117597   digestive organ expansion factor homolog (zebrafish)
Leishmania braziliensis LbrM.14.0420   hypothetical protein, conserved
Leishmania donovani LdBPK_140420.1   Protein of unknown function (DUF1253), putative
Leishmania infantum LinJ.14.0420   hypothetical protein, conserved
Leishmania major LmjF.14.0410   hypothetical protein, conserved
Leishmania mexicana LmxM.14.0410   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04023   hypothetical protein
Mus musculus ENSMUSG00000016181   digestive organ expansion factor homolog (zebrafish)
Neospora caninum NCLIV_035820   hypothetical protein
Oryza sativa 4338320   Os05g0295100
Onchocerca volvulus OVOC7530   Digestive organ expansion factor homolog
Plasmodium berghei PBANKA_1203400   U3 small nucleolar RNA-associated protein 25, putative
Plasmodium falciparum PF3D7_1005100   U3 small nucleolar RNA-associated protein 25, putative
Plasmodium knowlesi PKNH_0803800   U3 small nucleolar RNA-associated protein 25, putative
Plasmodium vivax PVX_094450   hypothetical protein, conserved
Plasmodium yoelii PY02979   Drosophila melanogaster CG3735 gene product
Saccharomyces cerevisiae YIL091C   Utp25p
Schistosoma japonicum Sjp_0207720   Digestive organ expansion factor homolog, putative
Schistosoma japonicum Sjp_0312610   Digestive organ expansion factor homolog, putative
Schistosoma mansoni Smp_158840   hypothetical protein
Schmidtea mediterranea mk4.000072.02   Digestive organ expansion factor homolog
Trypanosoma brucei gambiense Tbg972.7.4900   hypothetical protein, conserved
Trypanosoma brucei Tb927.7.4340   Protein of unknown function (DUF1253), putative
Trypanosoma congolense TcIL3000_7_3530   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508857.100   Protein of unknown function (DUF1253), putative
Trypanosoma cruzi TcCLB.504213.20   Protein of unknown function (DUF1253), putative
Toxoplasma gondii TGME49_270960   hypothetical protein
Theileria parva TP01_1213   hypothetical protein
Trichomonas vaginalis TVAG_075430   conserved hypothetical protein

Essentiality

Smp_158840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.4340 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.4340 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.4340 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.4340 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y41C4A.9 Caenorhabditis elegans slow growth wormbase
YIL091C Saccharomyces cerevisiae inviable yeastgenome
TGME49_270960 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_158840 (Schistosoma mansoni), hypothetical protein
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