Detailed view for Smp_162430

Basic information

TDR Targets ID: 286431
Schistosoma mansoni, mRNA-export factor tap/nxf-related
Source Database / ID:  GeneDB

pI: 9.6028 | Length (AA): 687 | MW (Da): 77130 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03943   TAP C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0051028   mRNA transport  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
79 342 1koh (A) 111 359 22.00 0 1 0.618379 -0.1
184 604 4wyk (A) 203 548 31.00 0 1 0.712909 0.64
203 310 4bsr (A) 352 451 43.00 0.48 0.71 0.404505 0.04
629 685 1oai (A) 561 617 32.00 0.0000000043 1 0.690069 -1.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129116)

Species Accession Gene Product
Brugia malayi Bm1_10740   TAP C-terminal domain containing protein
Candida albicans CaO19.8118   nuclear mRNA export
Candida albicans CaO19.488   nuclear mRNA export
Caenorhabditis elegans CELE_C15H11.3   Protein NXF-1, isoform B
Dictyostelium discoideum DDB_G0286415   hypothetical protein
Dictyostelium discoideum DDB_G0286455   hypothetical protein
Drosophila melanogaster Dmel_CG1664   small bristles
Drosophila melanogaster Dmel_CG32135   Nuclear export factor 3
Echinococcus granulosus EgrG_000183200   nuclear rna export factor 1
Entamoeba histolytica EHI_035490   hypothetical protein
Echinococcus multilocularis EmuJ_000183200   nuclear rna export factor 1
Homo sapiens ENSG00000162231   nuclear RNA export factor 1
Homo sapiens ENSG00000269437   nuclear RNA export factor 2B
Homo sapiens ENSG00000269405   nuclear RNA export factor 2
Loa Loa (eye worm) LOAG_09100   hypothetical protein
Mus musculus ENSMUSG00000010097   nuclear RNA export factor 1
Mus musculus ENSMUSG00000009941   nuclear RNA export factor 2
Mus musculus ENSMUSG00000031410   nuclear RNA export factor 7
Onchocerca volvulus OVOC8940  
Saccharomyces cerevisiae YPL169C   Mex67p
Schistosoma japonicum Sjp_0059070   Nuclear RNA export factor 1, putative
Schistosoma japonicum Sjp_0059060   IPR001611,Leucine-rich repeat,domain-containing
Schistosoma mansoni Smp_162430   mRNA-export factor tap/nxf-related
Schmidtea mediterranea mk4.023420.00  
Schmidtea mediterranea mk4.004032.02  
Schmidtea mediterranea mk4.004523.00  
Schmidtea mediterranea mk4.000521.14  
Schmidtea mediterranea mk4.004580.01  
Schmidtea mediterranea mk4.005142.00  
Schmidtea mediterranea mk4.003860.02  
Schmidtea mediterranea mk4.021895.00  
Trypanosoma cruzi TcCLB.508271.4   hypothetical protein, conserved

Essentiality

Smp_162430 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C15H11.3 Caenorhabditis elegans adult lethal wormbase
CELE_C15H11.3 Caenorhabditis elegans embryonic arrest wormbase
CELE_C15H11.3 Caenorhabditis elegans embryonic lethal wormbase
YPL169C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_162430 (Schistosoma mansoni), mRNA-export factor tap/nxf-related
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