Detailed view for Smp_172780

Basic information

TDR Targets ID: 286582
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.9213 | Length (AA): 872 | MW (Da): 98198 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00642   Zinc finger C-x8-C-x5-C-x3-H type (and similar)
PF05495   CHY zinc finger

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0008270   zinc ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 79 2d9n (A) 67 122 33.00 0 1 0.250786 0.65
29 75 1rgo (A) 158 219 43.00 0 0.85 0.144199 0.72
340 528 6ekv (A) 12 212 12.00 0 0 0.278043 -0.06
763 827 2dkt (A) 19 67 39.00 0.29 0.04 0.0593413 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132161)

Species Accession Gene Product
Babesia bovis BBOV_IV003110   CHY zinc finger domain containing protein
Brugia malayi Bm1_24215   CHY zinc finger family protein
Cryptosporidium hominis Chro.20367   hypothetical protein
Cryptosporidium parvum cgd2_3460   C- terminal region conserved, zinc finger, myb DNA binding domain
Echinococcus granulosus EgrG_001098800   Zinc finger CCCH type
Echinococcus multilocularis EmuJ_001098800   Zinc finger, CCCH type
Echinococcus multilocularis EmuJ_001099000   hypothetical protein
Giardia lamblia GL50803_15295   Zinc finger protein, putative
Loa Loa (eye worm) LOAG_05306   hypothetical protein
Loa Loa (eye worm) LOAG_05307   hypothetical protein
Neospora caninum NCLIV_070000   zinc finger (CHY type) protein, putative
Onchocerca volvulus OVOC7288  
Plasmodium berghei PBANKA_0831100   zinc finger protein, putative
Plasmodium falciparum PF3D7_0930400   zinc finger protein, putative
Plasmodium knowlesi PKNH_0729000   zinc finger protein, putative
Plasmodium vivax PVX_099985   hypothetical protein, conserved
Plasmodium yoelii PY01869   homeobox-containing protein
Plasmodium yoelii PY01868   putative zinc finger protein
Schistosoma japonicum Sjp_0317950   expressed protein
Schistosoma japonicum Sjp_0051750   IPR000571,Zinc finger, CCCH-type,domain-containing
Schistosoma mansoni Smp_172780   hypothetical protein
Toxoplasma gondii TGME49_306040   CHY zinc finger protein

Essentiality

Smp_172780 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0831100 Plasmodium berghei Dispensable plasmo
TGME49_306040 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_172780 (Schistosoma mansoni), hypothetical protein
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