Detailed view for Smp_158430

Basic information

TDR Targets ID: 286894
Schistosoma mansoni, ribonuclease t2
Source Database / ID:  GeneDB

pI: 7.2624 | Length (AA): 269 | MW (Da): 31665 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00445   Ribonuclease T2 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0033897   ribonuclease T2 activity  
GO:0003723   RNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 220 1bol (A) 7 220 20.00 0.0000086 0.54 0.901457 -0.09
17 222 1dix (A) 1 205 28.00 0 1 1.201 -1.06
23 205 1ucd (A) 1 179 30.00 0 1 1.0869 -1.34
23 243 3t0o (A) 34 251 30.00 0.000000000021 1 1.14576 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128552)

Species Accession Gene Product
Arabidopsis thaliana AT2G02990   ribonuclease 1
Arabidopsis thaliana AT2G39780   ribonuclease 2
Brugia malayi Bm1_50605   Ribonuclease T2 family protein
Candida albicans CaO19.3926   one ot three T2 family ribonucleases similar to S. cerevisiae RNY1 (YPL123C)
Candida albicans CaO19.3910   one ot three T2 family ribonucleases similar to S. cerevisiae RNY1 (YPL123C)
Candida albicans CaO19.11408   one ot three T2 family ribonucleases similar to S. cerevisiae RNY1 (YPL123C)
Candida albicans CaO19.11391   one ot three T2 family ribonucleases similar to S. cerevisiae RNY1 (YPL123C)
Caenorhabditis elegans CELE_K10C9.3   Protein K10C9.3
Dictyostelium discoideum DDB_G0295845   ribonuclease T2
Dictyostelium discoideum DDB_G0281293   ribonuclease T2
Drosophila melanogaster Dmel_CG8194   Ribonuclease X25
Echinococcus granulosus EgrG_000380250   ribonuclease t2
Entamoeba histolytica EHI_160710   ribonuclease, putative
Entamoeba histolytica EHI_169690   ribonuclease, putative
Echinococcus multilocularis EmuJ_000380250   ribonuclease t2
Homo sapiens ENSG00000026297   ribonuclease T2
Loa Loa (eye worm) LOAG_01286   hypothetical protein
Mus musculus 100037283   ribonuclease T2A
Mus musculus ENSMUSG00000094724   ribonuclease T2B
Oryza sativa 4325103   Os01g0897200
Oryza sativa 4345656   Os08g0434100
Oryza sativa 4325104   Os01g0897300
Saccharomyces cerevisiae YPL123C   Rny1p
Schistosoma japonicum Sjp_0219120   IPR001568,Ribonuclease T2,domain-containing
Schistosoma japonicum Sjp_0205850   Ribonuclease MC, putative
Schistosoma japonicum Sjp_0032830   Ribonuclease Oy, putative
Schistosoma japonicum Sjp_0202830   Ribonuclease Oy, putative
Schistosoma japonicum Sjp_0044760   expressed protein
Schistosoma japonicum Sjp_0032840   ko:K01172 similar to Ribonuclease Oy (RNase Oy) [EC:3.1.27.-], putative
Schistosoma japonicum Sjp_0201300   Ribonuclease S-3 precursor, putative
Schistosoma japonicum Sjp_0077130   Ribonuclease S-4 precursor, putative
Schistosoma japonicum Sjp_0202820   Ribonuclease 1 precursor, putative
Schistosoma japonicum Sjp_0205840   IPR001568,Ribonuclease T2,domain-containing
Schistosoma mansoni Smp_158430   ribonuclease t2
Schmidtea mediterranea mk4.012663.01   Putative ribonuclease t2
Schmidtea mediterranea mk4.008627.00  
Schmidtea mediterranea mk4.016251.00  
Schmidtea mediterranea mk4.013033.00  
Schmidtea mediterranea mk4.030308.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_158430 (Schistosoma mansoni), ribonuclease t2
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