Detailed view for Smp_171820.2

Basic information

TDR Targets ID: 286939
Schistosoma mansoni, neuropathy target esterase/swiss cheese-related protein
Source Database / ID:  GeneDB

pI: 7.943 | Length (AA): 1642 | MW (Da): 184557 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00027   Cyclic nucleotide-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008152   metabolic process  
GO:0006629   lipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
108 313 3bpz (A) 447 633 16.00 0.00000000011 0.99 0.295357 -0.33
175 315 5jix (A) 275 410 15.00 0 0.95 0.358171 -1.04
198 335 3la7 (A) 21 144 31.00 0.036 0.8 0.396244 -0.39
495 760 5kbf (A) 151 428 16.00 0 1 0.314898 0.35
650 760 1o5l (A) 5 116 19.00 0 0.92 0.3469 -0.31
652 789 4r8h (A) 9 159 27.00 0.057 0.66 0.254244 0.39
1017 1288 5fya (A) 23 311 22.00 0 1 0.308552 0.05
1019 1186 5fya (A) 25 233 30.00 0.00000000038 0.87 0.260514 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128271)

Species Accession Gene Product
Brugia malayi Bm1_00930   Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative
Candida albicans CaO19.13754   similar to S. cerevisiae YML059C predicted ER hydrolase
Candida albicans CaO19.6396   similar to S. cerevisiae YML059C predicted ER hydrolase
Caenorhabditis elegans CELE_M110.7   Protein M110.7
Caenorhabditis elegans CELE_ZK370.4   Protein ZK370.4, isoform A
Drosophila melanogaster Dmel_CG2212   swiss cheese
Escherichia coli b1234   putative patatin-like family phospholipase
Echinococcus granulosus EgrG_000199200   patatin phospholipase domain containing protein
Echinococcus multilocularis EmuJ_000199200   patatin phospholipase domain containing protein
Homo sapiens ENSG00000130653   patatin-like phospholipase domain containing 7
Homo sapiens ENSG00000032444   patatin-like phospholipase domain containing 6
Loa Loa (eye worm) LOAG_04599   hypothetical protein
Mus musculus ENSMUSG00000004565   patatin-like phospholipase domain containing 6
Mus musculus ENSMUSG00000036833   patatin-like phospholipase domain containing 7
Mycobacterium tuberculosis Rv2565   Conserved protein
Onchocerca volvulus OVOC7831  
Saccharomyces cerevisiae YML059C   Nte1p
Schistosoma japonicum Sjp_0108950   expressed protein
Schistosoma mansoni Smp_171820.1   neuropathy target esterase/swiss cheese-related protein
Schistosoma mansoni Smp_171820.2   neuropathy target esterase/swiss cheese-related protein
Schmidtea mediterranea mk4.035485.00   Neuropathy target esterase sws
Schmidtea mediterranea mk4.031677.00  
Schmidtea mediterranea mk4.019462.00  
Schmidtea mediterranea mk4.008911.01   Neuropathy target esterase sws
Treponema pallidum TP1033   hypothetical protein

Essentiality

Smp_171820.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2609 Mycobacterium tuberculosis non-essential nmpdr
b1234 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus patatin-like phospholipase domain containing 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_171820.2 (Schistosoma mansoni), neuropathy target esterase/swiss cheese-related protein
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