Detailed view for Smp_014660.2

Basic information

TDR Targets ID: 286970
Schistosoma mansoni, rab-related GTP-binding protein
Source Database / ID:  GeneDB

pI: 8.14 | Length (AA): 205 | MW (Da): 23086 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0005515   protein binding  
GO:0003924   GTPase activity  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  
GO:0006913   nucleocytoplasmic transport  
GO:0006886   intracellular protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 175 5szj (A) 1 175 63.00 0 1 1.70776 -1.32
1 175 2gf9 (A) 14 188 48.00 0 1 1.53066 -1.1
4 189 2bcg (Y) 3 188 50.00 0 1 1.63742 -1.38
6 173 3rwo (B) 10 177 50.00 0 1 1.56751 -1.61
12 112 4fmc (F) 14 114 64.00 0 0.84 0.630083 1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127321)

Species Accession Gene Product
Arabidopsis thaliana AT3G53610   RAB GTPase-8
Arabidopsis thaliana AT5G59840   Ras-related small GTP-binding family protein
Arabidopsis thaliana AT3G46060   small GTP-binding protein ARA3
Arabidopsis thaliana AT3G09900   RAB GTPase-like protein E1E
Brugia malayi Bm1_47575   Rab family protein 8
Brugia malayi Bm1_48835   Ras-related protein Rab-10
Candida albicans CaO19.10103   Ras-related protein similar to S. cerevisiae SEC4 (YFL005W) secretory vesicle associated Rab GTPase that binds to Sec15p and is
Candida albicans CaO19.2571   Ras-related protein similar to S. cerevisiae SEC4 (YFL005W) secretory vesicle associated Rab GTPase that binds to Sec15p and is
Caenorhabditis elegans CELE_T23H2.5   Protein RAB-10
Caenorhabditis elegans CELE_D1037.4   Protein RAB-8
Dictyostelium discoideum DDB_G0276399   Rab GTPase
Dictyostelium discoideum DDB_G0280043   Rab GTPase
Drosophila melanogaster Dmel_CG17060   CG17060 gene product from transcript CG17060-RA
Drosophila melanogaster Dmel_CG8287   CG8287 gene product from transcript CG8287-RA
Echinococcus granulosus EgrG_001003300   ras protein rab 8b
Echinococcus granulosus EgrG_001176700   ras protein Rab 10
Entamoeba histolytica EHI_199820   Rab family GTPase
Echinococcus multilocularis EmuJ_001003300   ras protein rab 8b
Echinococcus multilocularis EmuJ_001176700   ras protein Rab 10
Homo sapiens ENSG00000166128   RAB8B, member RAS oncogene family
Homo sapiens 4218   RAB8A, member RAS oncogene family
Homo sapiens ENSG00000084733   RAB10, member RAS oncogene family
Loa Loa (eye worm) LOAG_10079   RAB-10 protein
Mus musculus ENSMUSG00000036943   RAB8B, member RAS oncogene family
Mus musculus ENSMUSG00000020671   RAB10, member RAS oncogene family
Mus musculus 17274   RAB8A, member RAS oncogene family
Oryza sativa 4334590   Os03g0819900
Oryza sativa 4339021   Os05g0461300
Oryza sativa 4342802   Os07g0239400
Saccharomyces cerevisiae YFL005W   Rab family GTPase SEC4
Schistosoma japonicum Sjp_0041080   ko:K07976 Rab family, other, putative
Schistosoma japonicum Sjp_0023950   ko:K07976 Rab family, other, putative
Schistosoma mansoni Smp_104670   rab15 13 10 1 35 5 and
Schistosoma mansoni Smp_014660.1   rab-related GTP-binding protein
Schistosoma mansoni Smp_014660.2   rab-related GTP-binding protein
Schmidtea mediterranea mk4.002894.00  
Schmidtea mediterranea mk4.000086.02  
Schmidtea mediterranea mk4.003653.02  
Schmidtea mediterranea mk4.019657.00  
Schmidtea mediterranea mk4.002257.00  
Schmidtea mediterranea mk4.000504.06  
Schmidtea mediterranea mk4.016674.01   Ras-related protein Rab-8B

Essentiality

Smp_014660.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_D1037.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_T23H2.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T23H2.5 Caenorhabditis elegans larval arrest wormbase
CELE_T23H2.5 Caenorhabditis elegans sterile wormbase
YFL005W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_014660.2 (Schistosoma mansoni), rab-related GTP-binding protein
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