Detailed view for Smp_167570.2

Basic information

TDR Targets ID: 287205
Schistosoma mansoni, negative cofactor 2 transcriptional co-repressor (nc2)
Source Database / ID:  GeneDB

pI: 11.053 | Length (AA): 278 | MW (Da): 30784 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00808   Histone-like transcription factor (CBF/NF-Y) and archaeal histone

Gene Ontology

Mouse over links to read term descriptions.
GO:0046982   protein heterodimerization activity  
GO:0005622   intracellular  
GO:0043565   sequence-specific DNA binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
89 154 1jfi (A) 10 75 57.00 0 0.88 0.85791 -0.12
91 238 1f1e (A) 5 151 12.00 0 0.13 0.714274 -0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129557)

Species Accession Gene Product
Arabidopsis thaliana AT3G12480   nuclear factor Y, subunit C11
Arabidopsis thaliana AT5G19490   Histone superfamily protein
Brugia malayi Bm1_50560   transcription regulator NC2 alpha chain - human, putative
Candida albicans CaO19.10250   similar to S. cerevisiae BUR6 (YER159C) subunit of NC2 RNA Pol II transcriptional regulator
Candida albicans CaO19.2736   similar to S. cerevisiae BUR6 (YER159C) subunit of NC2 RNA Pol II transcriptional regulator
Caenorhabditis elegans CELE_F40F9.7   Protein DRAP-1, isoform B
Dictyostelium discoideum DDB_G0292510   hypothetical protein
Drosophila melanogaster Dmel_CG10318   Negative Cofactor 2alpha
Echinococcus granulosus EgrG_000125800   dr1 associated corepressor
Entamoeba histolytica EHI_009610   CBF/NF-Y transcription factor family protein
Echinococcus multilocularis EmuJ_000125800   dr1 associated corepressor
Homo sapiens ENSG00000175550   DR1-associated protein 1 (negative cofactor 2 alpha)
Loa Loa (eye worm) LOAG_01283   transcription regulator NC2 alpha chain
Mus musculus ENSMUSG00000024914   Dr1 associated protein 1 (negative cofactor 2 alpha)
Oryza sativa 4350685   Os11g0544700
Oryza sativa 4339189   Os05g0494100
Saccharomyces cerevisiae YER159C   Bur6p
Schistosoma japonicum Sjp_0071870   Dr1-associated corepressor, putative
Schistosoma mansoni Smp_167570.1   negative cofactor 2 transcriptional co-repressor (nc2)
Schistosoma mansoni Smp_167570.2   negative cofactor 2 transcriptional co-repressor (nc2)
Schmidtea mediterranea mk4.001705.02   Dr1-associated corepressor

Essentiality

Smp_167570.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YER159C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_167570.2 (Schistosoma mansoni), negative cofactor 2 transcriptional co-repressor (nc2)
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