Detailed view for Smp_194840

Basic information

TDR Targets ID: 287209
Schistosoma mansoni, niemann pick c2 (NPC2)
Source Database / ID:  GeneDB

pI: 8.2759 | Length (AA): 60 | MW (Da): 6703 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Lysosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
15 44 5f8h (A) 331 363 50.00 0.11 0.2 0.8382 0.62
17 60 5kwy (C) 20 63 39.00 0 0.77 1.17613 0.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133467)

Species Accession Gene Product
Brugia malayi Bm1_35600   ML domain containing protein
Caenorhabditis elegans CELE_R148.6   Protein HEH-1
Drosophila melanogaster Dmel_CG7291   Niemann-Pick type C-2a
Echinococcus granulosus EgrG_000682900   Niemann Pick C2 protein
Echinococcus multilocularis EmuJ_000682900   Niemann Pick C2 protein
Homo sapiens ENSG00000119655   Niemann-Pick disease, type C2
Loa Loa (eye worm) LOAG_00908   ML domain-containing protein
Mus musculus ENSMUSG00000021242   Niemann-Pick type C2
Schistosoma japonicum Sjp_0215260   Epididymal secretory protein E1 precursor, putative
Schistosoma japonicum Sjp_0317700   IPR003172,E1 protein and Def2/Der2 allergen,domain-containing
Schistosoma mansoni Smp_194840   niemann pick c2 (NPC2)
Schmidtea mediterranea mk4.026117.01  
Schmidtea mediterranea mk4.005262.01  
Schmidtea mediterranea mk4.021214.00  
Schmidtea mediterranea mk4.000723.03  
Schmidtea mediterranea mk4.002936.00  
Schmidtea mediterranea mk4.017421.00  
Schmidtea mediterranea mk4.004268.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_194840 (Schistosoma mansoni), niemann pick c2 (NPC2)
Title for this comment
Comment