Detailed view for PF3D7_1457000

Basic information

TDR Targets ID: 2873
Plasmodium falciparum, signal peptide peptidase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.0582 | Length (AA): 412 | MW (Da): 47579 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04258   Signal peptide peptidase

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0008150   biological_process  
GO:0016021   integral to membrane  
GO:0004190   aspartic-type endopeptidase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 127 3udc (A) 20 104 32.00 0.25 0.09 0.172218 2.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128374)

Species Accession Gene Product
Arabidopsis thaliana AT2G03120   signal peptide peptidase
Brugia malayi Bm1_39720   Hypothetical 52.8 kDa protein T05E11.5 in chromosome IV
Caenorhabditis elegans CELE_T05E11.5   Protein IMP-2
Cryptosporidium hominis Chro.60109   multi-pass transmembrane protein
Cryptosporidium parvum cgd6_840   shanti/Ykl100cp/Minor histocompatibility antigen H13-like; presenilin, signal peptide peptidase family, with 10 transmembrane do
Dictyostelium discoideum DDB_G0292836   peptidase A22B family protein
Drosophila melanogaster Dmel_CG11840   Signal peptide peptidase
Echinococcus granulosus EgrG_000084000   Minor histocompatibility antigen H13
Entamoeba histolytica EHI_031250   signal peptidase, putative
Echinococcus multilocularis EmuJ_000084000   Minor histocompatibility antigen H13
Giardia lamblia GL50803_8429   Minor histocompatibility antigen H13
Homo sapiens ENSG00000101294   histocompatibility (minor) 13
Leishmania braziliensis LbrM.29.0980   signal peptide peptidase, putative,aspartic peptidase, clan AD, family A22B, putative
Leishmania donovani LdBPK_290990.1   signal peptide peptidase, putative
Leishmania infantum LinJ.29.0990   signal peptide peptidase, putative,aspartic peptidase, clan AD, family A22B, putative
Leishmania major LmjF.29.0910   signal peptide peptidase, putative,aspartic peptidase, clan AD, family A22B, putative
Leishmania mexicana LmxM.08_29.0910   signal peptide peptidase, putative,aspartic peptidase, clan AD, family A22B, putative
Loa Loa (eye worm) LOAG_11844   hypothetical protein
Loa Loa (eye worm) LOAG_04660   hypothetical protein
Mus musculus ENSMUSG00000019188   histocompatibility 13
Neospora caninum NCLIV_051010   signal peptide peptidase domain-containing protein, putative
Oryza sativa 4328088   Os02g0117400
Oryza sativa 4338901   Os05g0436400
Plasmodium berghei PBANKA_1320700   signal peptide peptidase, putative
Plasmodium falciparum PF3D7_1457000   signal peptide peptidase
Plasmodium knowlesi PKNH_1224800   signal peptide peptidase, putative
Plasmodium vivax PVX_117615   signal peptide peptidase, putative
Plasmodium yoelii PY06507   Homo sapiens dJ324O17.1.2-related
Saccharomyces cerevisiae YKL100C   hypothetical protein
Schistosoma japonicum Sjp_0212410   ko:K09595 minor histocompatibility antigen H13, putative
Schistosoma mansoni Smp_099430   signal peptide peptidase
Schmidtea mediterranea mk4.001765.04   Intramembrane protease 2
Trypanosoma brucei gambiense Tbg972.3.5500   signal peptide peptidase, putative,aspartic peptidase, clan AD, family A22B, putative
Trypanosoma brucei Tb927.3.4910   signal peptide peptidase, putative
Trypanosoma congolense TcIL3000_3_2960   signal peptide peptidase, putative
Trypanosoma cruzi TcCLB.507951.260   signal peptide peptidase, putative
Toxoplasma gondii TGME49_237150   minor histocompatibility antigen h13, putative
Trichomonas vaginalis TVAG_074490   Clan AD, family A22, presenilin-like aspartic peptidase

Essentiality

PF3D7_1457000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.4910 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.3.4910 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.3.4910 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.4910 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05E11.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05E11.5 Caenorhabditis elegans larval arrest wormbase
CELE_T05E11.5 Caenorhabditis elegans larval lethal wormbase
CELE_T05E11.5 Caenorhabditis elegans slow growth wormbase
PBANKA_1320700 Plasmodium berghei Essential plasmo
TGME49_237150 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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