Detailed view for Smp_159280

Basic information

TDR Targets ID: 287567
Schistosoma mansoni, crisp subfamily glioma pathogenesis-related protein-related
Source Database / ID:  GeneDB

pI: 9.6494 | Length (AA): 222 | MW (Da): 25882 | Paralog Number: 22

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005576   extracellular region  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 169 4p27 (A) 4 158 27.00 0 0.99 0.84834 -0.3
28 169 4p27 (A) 4 158 35.00 0.0000000000069 1 0.83404 -0.06
29 167 2vzn (B) 40 214 28.00 0 0.99 0.725826 -0.01
122 167 2vzn (A) 165 214 52.00 0.00004 0.22 0.489607 0.68

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 4P27:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127475)

Species Accession Gene Product
Arabidopsis thaliana AT2G19980   CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein
Arabidopsis thaliana AT3G19690   putative pathogenesis-related protein
Arabidopsis thaliana AT2G14610   pathogenesis-related protein 1
Arabidopsis thaliana AT4G33710   putative pathogenesis-related protein
Arabidopsis thaliana AT5G26130   Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein superfamily protein
Arabidopsis thaliana AT2G19970   putative pathogenesis-related protein
Arabidopsis thaliana AT2G14580   pathogenesis-related protein 1
Brugia malayi Bm1_34090   SCP-like extracellular protein
Caenorhabditis elegans CELE_F49E11.9   Protein SCL-1
Caenorhabditis elegans CELE_F49E11.6   Protein SCL-11
Echinococcus granulosus EgrG_000709300   GLIPR1 protein 1
Echinococcus granulosus EgrG_000096500   peptidase inhibitor 16
Echinococcus granulosus EgrG_001147500   Allergen V5 Tpx 1
Echinococcus granulosus EgrG_001147400   venom allergen val protein
Echinococcus granulosus EgrG_000781600   venom allergen val protein
Echinococcus granulosus EgrG_001147700   peptidase inhibitor 16
Echinococcus multilocularis EmuJ_000651500   peptidase inhibitor R3HDML
Echinococcus multilocularis EmuJ_000291500   glioma pathogenesis protein 1
Echinococcus multilocularis EmuJ_000781600   venom allergen (val) protein
Echinococcus multilocularis EmuJ_001147400   venom allergen (val) protein cysteine rich secreted protein
Echinococcus multilocularis EmuJ_000096500   peptidase inhibitor 16
Echinococcus multilocularis EmuJ_000682500   GLI pathogenesis 1 (glioma)
Echinococcus multilocularis EmuJ_000709300   GLIPR1 protein 1
Echinococcus multilocularis EmuJ_001147500   Allergen V5 Tpx 1
Echinococcus multilocularis EmuJ_000290800   glioma pathogenesis protein 1
Homo sapiens ENSG00000173401   GLI pathogenesis-related 1 like 1
Homo sapiens ENSG00000164530   peptidase inhibitor 16
Loa Loa (eye worm) LOAG_03326   hypothetical protein
Mus musculus ENSMUSG00000024011   peptidase inhibitor 16
Mus musculus 544736   GLI pathogenesis-related 1 like 3
Mus musculus ENSMUSG00000020213   GLI pathogenesis-related 1 like 1
Neospora caninum NCLIV_000710   hypothetical protein, conserved
Oryza sativa 4325424   Os01g0382400
Oryza sativa 4342318   Os07g0129300
Oryza sativa 4348237   Os10g0191300
Oryza sativa 4342317   Os07g0129200
Oryza sativa 4342311   Os07g0125000
Oryza sativa 4342310   Os07g0124900
Oryza sativa 9270927   Os07g0126400
Oryza sativa 4342316   Os07g0128800
Oryza sativa 4325422   Os01g0382000
Oryza sativa 4342314   Os07g0127600
Onchocerca volvulus OVOC2681  
Saccharomyces cerevisiae YJL078C   Pry3p
Schistosoma japonicum Sjp_0216320   GLIPR1-like protein 1 precursor, putative
Schistosoma japonicum Sjp_0305270   Pathogenesis-related leaf protein 4 precursor, putative
Schistosoma japonicum Sjp_0008960   GLIPR1-like protein 1 precursor, putative
Schistosoma japonicum Sjp_0112690   expressed protein
Schistosoma japonicum Sjp_0038930   GLIPR1-like protein 1 precursor, putative
Schistosoma japonicum Sjp_0038950   Peptidase inhibitor 16 precursor, putative
Schistosoma japonicum Sjp_0038960   GLIPR1-like protein 1 precursor, putative
Schistosoma japonicum Sjp_0038970   Glioma pathogenesis-related protein 1 precursor, putative
Schistosoma japonicum Sjp_0039030   Peptidase inhibitor 16 precursor, putative
Schistosoma japonicum Sjp_0088640   IPR001283,Allergen V5/Tpx-1 related;IPR002413,Ves allergen,domain-containing
Schistosoma mansoni Smp_001890   venom allergen-like (VAL) 18 protein
Schistosoma mansoni Smp_116210   hypothetical protein
Schistosoma mansoni Smp_002630   venom allergen-like (VAL) 2 protein
Schistosoma mansoni Smp_002070   venom allergen-like (VAL) 4 protein
Schistosoma mansoni Smp_123090   venom allergen-like (VAL) 19 protein
Schistosoma mansoni Smp_139450   venom allergen-like (VAL) 22 protein
Schistosoma mansoni Smp_159280   crisp subfamily glioma pathogenesis-related protein-related
Schistosoma mansoni Smp_176180   venom allergen-like (VAL) 9 protein
Schistosoma mansoni Smp_154260   venom allergen-like (VAL) 26 protein
Schistosoma mansoni Smp_123550   venom allergen-like (VAL) 8 protein
Schistosoma mansoni Smp_176160   venom allergen-like (VAL) 28 protein
Schistosoma mansoni Smp_078490   Venom allergen-like (VAL) 14 protein
Schistosoma mansoni Smp_123540   venom allergen-like (VAL) protein 12
Schistosoma mansoni Smp_120240   venom allergen-like (VAL) 1 protein
Schistosoma mansoni Smp_100560   hypothetical protein
Schistosoma mansoni Smp_176170   hypothetical protein
Schistosoma mansoni Smp_159290   venom allergen-like (VAL) 21 protein
Schistosoma mansoni Smp_179480   venom allergen-like (VAL) 5 protein
Schistosoma mansoni Smp_070250   venom allergen-like (VAL) 15 protein
Schistosoma mansoni Smp_154290   venom allergen-like (VAL) 27 protein
Schistosoma mansoni Smp_002060   venom allergen-like (VAL) 10 protein
Schistosoma mansoni Smp_118160   hypothetical protein
Schistosoma mansoni Smp_070240   venom allergen-like (VAL) 7 protein
Schmidtea mediterranea mk4.017732.01  
Schmidtea mediterranea mk4.001052.01  
Schmidtea mediterranea mk4.010177.00  
Schmidtea mediterranea mk4.005192.03  
Schmidtea mediterranea mk4.006133.00  
Schmidtea mediterranea mk4.012014.00  
Schmidtea mediterranea mk4.000923.03  
Schmidtea mediterranea mk4.023768.00  
Schmidtea mediterranea mk4.003760.13  
Schmidtea mediterranea mk4.036912.00  
Schmidtea mediterranea mk4.040294.00  
Schmidtea mediterranea mk4.004170.06  
Schmidtea mediterranea mk4.000294.12  
Schmidtea mediterranea mk4.002930.10  
Schmidtea mediterranea mk4.011300.02  
Schmidtea mediterranea mk4.002969.00  
Schmidtea mediterranea mk4.001441.00  
Schmidtea mediterranea mk4.011300.01  
Schmidtea mediterranea mk4.000194.09  
Schmidtea mediterranea mk4.010596.01  
Schmidtea mediterranea mk4.005029.01  
Schmidtea mediterranea mk4.002723.01  
Schmidtea mediterranea mk4.001974.00  
Schmidtea mediterranea mk4.004819.04  
Schmidtea mediterranea mk4.012014.01  
Schmidtea mediterranea mk4.000201.06  
Schmidtea mediterranea mk4.020137.00  
Schmidtea mediterranea mk4.000201.07  
Schmidtea mediterranea mk4.000201.05  
Schmidtea mediterranea mk4.000336.00   GLIPR1-like protein 1
Schmidtea mediterranea mk4.001082.05  
Schmidtea mediterranea mk4.001052.00  
Schmidtea mediterranea mk4.028756.01  
Schmidtea mediterranea mk4.012504.00  
Schmidtea mediterranea mk4.014431.01  
Schmidtea mediterranea mk4.014768.02  
Schmidtea mediterranea mk4.000194.06  
Schmidtea mediterranea mk4.014764.01  
Schmidtea mediterranea mk4.011300.00  
Schmidtea mediterranea mk4.001981.05  
Schmidtea mediterranea mk4.002628.03  
Schmidtea mediterranea mk4.004476.01  
Schmidtea mediterranea mk4.000336.10   Peptidase inhibitor 15
Schmidtea mediterranea mk4.000294.09  
Schmidtea mediterranea mk4.027017.00   GLIPR1-like protein 2
Schmidtea mediterranea mk4.010177.02  
Schmidtea mediterranea mk4.007066.01  
Schmidtea mediterranea mk4.020137.01  
Schmidtea mediterranea mk4.002483.03  
Schmidtea mediterranea mk4.004170.02  
Schmidtea mediterranea mk4.043162.01  
Schmidtea mediterranea mk4.014214.00  
Schmidtea mediterranea mk4.009004.00  
Schmidtea mediterranea mk4.000294.16  
Schmidtea mediterranea mk4.009311.00  
Schmidtea mediterranea mk4.003568.01  
Schmidtea mediterranea mk4.001666.02   GLIPR1-like protein 1
Schmidtea mediterranea mk4.006062.01   Peptidase inhibitor 15-A
Schmidtea mediterranea mk4.000294.10  
Toxoplasma gondii TGME49_239890   SCP family extracellular subfamily protein

Essentiality

Smp_159280 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_239890 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_159280 (Schistosoma mansoni), crisp subfamily glioma pathogenesis-related protein-related
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