Detailed view for Smp_162260

Basic information

TDR Targets ID: 287649
Schistosoma mansoni, phosphatidylinositol-binding clathrin assembly protein
Source Database / ID:  GeneDB

pI: 5.4336 | Length (AA): 742 | MW (Da): 80143 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07651   ANTH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030136   clathrin-coated vesicle  
GO:0030118   clathrin coat  
GO:0030276   clathrin binding  
GO:0005545   phosphatidylinositol binding  
GO:0005543   phospholipid binding  
GO:0048268   clathrin coat assembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
21 300 3zym (A) 5 1032 56.00 0 1 1.18146 -1.72
37 302 1hx8 (A) 23 299 56.00 0 1 1.16359 -1.93
244 320 4e5y (D) 214 288 28.00 0.71 0.09 0.286874 0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127500)

Species Accession Gene Product
Arabidopsis thaliana AT2G01600   putative clathrin assembly protein
Arabidopsis thaliana AT5G57200   putative clathrin assembly protein
Arabidopsis thaliana AT4G25940   ENTH/ANTH/VHS superfamily protein
Arabidopsis thaliana AT5G35200   putative clathrin assembly protein
Arabidopsis thaliana AT1G14910   putative clathrin assembly protein
Brugia malayi Bm1_22460   ANTH domain containing protein
Candida albicans CaO19.4184   contains epsin-like N terminal domain similar to S. cerevisiae YAP1801 (YHR161C) clathrin-binding protein
Candida albicans CaO19.11660   contains epsin-like N terminal domain similar to S. cerevisiae YAP1801 (YHR161C) clathrin-binding protein
Caenorhabditis elegans CELE_C32E8.10   Protein UNC-11, isoform F
Dictyostelium discoideum DDB_G0278685   ANTH domain-containing protein
Drosophila melanogaster Dmel_CG2520   like-AP180
Echinococcus granulosus EgrG_000169300   phosphatidylinositol binding clathrin assembly
Echinococcus multilocularis EmuJ_001108000   phosphatidylinositol binding clathrin assembly
Echinococcus multilocularis EmuJ_000169300   phosphatidylinositol binding clathrin assembly
Homo sapiens ENSG00000065609   synaptosomal-associated protein, 91kDa
Homo sapiens ENSG00000073921   phosphatidylinositol binding clathrin assembly protein
Leishmania braziliensis LbrM.24.0020   clathrin coat assembly protein, putative
Leishmania donovani LdBPK_240020.1   clathrin coat assembly protein, putative
Leishmania infantum LinJ.24.0020   clathrin coat assembly protein, putative
Leishmania major LmjF.24.0020   clathrin coat assembly protein, putative
Leishmania mexicana LmxM.24.0020   clathrin coat assembly protein, putative
Loa Loa (eye worm) LOAG_05925   hypothetical protein
Loa Loa (eye worm) LOAG_05926   hypothetical protein
Mus musculus ENSMUSG00000039361   phosphatidylinositol binding clathrin assembly protein
Mus musculus ensembl-mmu:ENSMUSG00000033419   synaptosomal-associated protein 91
Oryza sativa 4328473   Os02g0175700
Oryza sativa 4339517   Os05g0549000
Oryza sativa 4340282   Os06g0175500
Oryza sativa 9266390   Os06g0661400
Oryza sativa 4331047   Os02g0803300
Saccharomyces cerevisiae YGR241C   Yap1802p
Saccharomyces cerevisiae YHR161C   Yap1801p
Schistosoma japonicum Sjp_0134940   Phosphatidylinositol-binding clathrin assembly protein unc-11, putative
Schistosoma mansoni Smp_162260   phosphatidylinositol-binding clathrin assembly protein
Schmidtea mediterranea mk4.001729.02   Phosphatidylinositol-binding clathrin assembly protein unc-11
Schmidtea mediterranea mk4.002809.00   Phosphatidylinositol-binding clathrin assembly protein unc-11
Trypanosoma brucei gambiense Tbg972.11.5420   clathrin coat assembly protein, putative
Trypanosoma brucei Tb927.11.4800   clathrin coat assembly protein, putative
Trypanosoma congolense TcIL3000_0_14620   clathrin coat assembly protein, putative
Trypanosoma cruzi TcCLB.503449.30   clathrin coat assembly protein, putative
Trypanosoma cruzi TcCLB.509875.190   clathrin coat assembly protein, putative

Essentiality

Smp_162260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.2410 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.2410 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.02.2410 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.2410 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C32E8.10 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_162260 (Schistosoma mansoni), phosphatidylinositol-binding clathrin assembly protein
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