Detailed view for Smp_146300

Basic information

TDR Targets ID: 287798
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.9531 | Length (AA): 630 | MW (Da): 70707 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05063   MT-A70

Gene Ontology

Mouse over links to read term descriptions.
GO:0016422   mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity  
GO:0005634   nucleus  
GO:0008168   methyltransferase activity  
GO:0001510   RNA methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 199 4uos (A) 3 176 6.00 0.065 0.01 0.420616 -1.29
268 367 5yz9 (A) 261 357 49.00 0.72 0.88 0.54333 1.31
420 628 5l6d (A) 368 576 80.00 0 1 1.21285 -1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129618)

Species Accession Gene Product
Arabidopsis thaliana AT4G10760   N6-adenosine-methyltransferase MT-A70-like protein
Babesia bovis BBOV_III001900   MT-A70 family protein
Candida albicans CaO19.1476   Activator of IME1 (meiosis)
Candida albicans CaO19.9051   Activator of IME1 (meiosis)
Drosophila melanogaster Dmel_CG5933   Inducer of meiosis 4
Echinococcus granulosus EgrG_000328700   n6 adenosine methyltransferase ime4
Echinococcus granulosus EgrG_000651200   n6 adenosine methyltransferase 70 kDa
Echinococcus granulosus EgrG_001112100   N6 adenosine methyltransferase 70 kDa subunit
Echinococcus multilocularis EmuJ_000651200   n6 adenosine methyltransferase 70 kDa
Echinococcus multilocularis EmuJ_000328700   n6 adenosine methyltransferase ime4
Homo sapiens ENSG00000165819   methyltransferase like 3
Mus musculus ENSMUSG00000022160   methyltransferase like 3
Neospora caninum NCLIV_062110   N6-adenosine-methyltransferase 70 kDa subunit, putative
Oryza sativa 4330284   Os02g0672600
Plasmodium berghei PBANKA_0213600   mRNA (N6-adenosine)-methyltransferase, putative
Plasmodium falciparum PF3D7_0729500   mRNA (N6-adenosine)-methyltransferase, putative
Plasmodium knowlesi PKNH_0214400   mRNA (N6-adenosine)-methyltransferase, putative
Plasmodium vivax PVX_081775   hypothetical protein, conserved
Plasmodium yoelii PY01472   hypothetical protein
Saccharomyces cerevisiae YGL192W   Ime4p
Schistosoma japonicum Sjp_0047440   ko:K05925 mRNA (2'-O-methyladenosine-N6-)-methyltransferase [EC2.1.1.62], putative
Schistosoma mansoni Smp_146300   hypothetical protein
Schmidtea mediterranea mk4.000368.00   N6-adenosine-methyltransferase 70 kDa subunit
Toxoplasma gondii TGME49_217350   methyltransferase MTA70, putative
Trichomonas vaginalis TVAG_136190   n6-adenosine-methyltransferase ime4, putative
Trichomonas vaginalis TVAG_389630   n6-adenosine-methyltransferase ime4, putative
Trichomonas vaginalis TVAG_002370   n6-adenosine-methyltransferase ime4, putative
Trichomonas vaginalis TVAG_062450   n6-adenosine-methyltransferase ime4, putative

Essentiality

Smp_146300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0213600 Plasmodium berghei Essential plasmo
TGME49_217350 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_146300 (Schistosoma mansoni), hypothetical protein
Title for this comment
Comment