Detailed view for Smp_001830.1

Basic information

TDR Targets ID: 288108
Schistosoma mansoni, 60S ribosomal protein L24
Source Database / ID:  GeneDB

pI: 11.4978 | Length (AA): 157 | MW (Da): 18187 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01246   Ribosomal protein L24e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
41 152 4dvy (P) 556 670 30.00 0.48 0.5 0.932376 -0.48
84 154 1x59 (A) 1 73 35.00 0.18 0.06 0.763229 -0.14
93 149 1gmj (A) 24 81 30.00 0.2 0.09 0.868457 -2.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127273)

Species Accession Gene Product
Arabidopsis thaliana AT2G36620   60S ribosomal protein L24-1
Arabidopsis thaliana AT3G53020   60S ribosomal protein L24-2
Babesia bovis BBOV_III003570   ribosomal protein L24e, putative
Brugia malayi Bm1_06190   60S ribosomal protein L24 (L30)
Candida albicans CaO19.3789   likely cytosolic ribosomal protein similar to S. cerevisiae RPL24A (YGL031C) large subunit protein L24A
Candida albicans CaO19.11269   likely cytosolic ribosomal protein similar to S. cerevisiae RPL24A (YGL031C) large subunit protein L24A
Caenorhabditis elegans CELE_D1007.12   Protein RPL-24.1
Cryptosporidium hominis Chro.40103   ribosomal protein L24e
Cryptosporidium parvum cgd4_840   possible 60S ribosomal protein L24
Dictyostelium discoideum DDB_G0280229   S60 ribosomal protein L24
Drosophila melanogaster Dmel_CG9282   Ribosomal protein L24
Echinococcus granulosus EgrG_000040000   ribosomal protein L24
Entamoeba histolytica EHI_030760   60S ribosomal protein L24, putative
Entamoeba histolytica EHI_153080   60S ribosomal protein L24, putative
Echinococcus multilocularis EmuJ_000040000   ribosomal protein L24
Homo sapiens ENSG00000114391   ribosomal protein L24
Leishmania braziliensis LbrM.35.1230   ribosomal protein L24, putative
Leishmania braziliensis LbrM.35.1200   ribosomal protein L24, putative
Leishmania infantum LinJ.36.1130   ribosomal protein L24, putative
Leishmania infantum LinJ.36.1160   ribosomal protein L24, putative
Leishmania major LmjF.36.1100   ribosomal protein L24, putative
Leishmania major LmjF.36.1070   ribosomal protein L24, putative
Leishmania mexicana LmxM.36.1100   ribosomal protein L24, putative
Leishmania mexicana LmxM.36.1070   ribosomal protein L24, putative
Loa Loa (eye worm) LOAG_15187   hypothetical protein
Mus musculus ENSMUSG00000098274   ribosomal protein L24
Mus musculus 102639220   predicted gene, 17430
Neospora caninum NCLIV_018890   L24, related
Oryza sativa 4339145   Os05g0486700
Oryza sativa 4327483   Os01g0815800
Oryza sativa 4342748   Os07g0224000
Plasmodium berghei PBANKA_1407600   60S ribosomal protein L24, putative
Plasmodium falciparum PF3D7_1309100   60S ribosomal protein L24, putative
Plasmodium knowlesi PKNH_1409500   60S ribosomal protein L24, putative
Plasmodium vivax PVX_122285   60S ribosomal protein L24, putative
Plasmodium yoelii PY06973   Ribosomal protein L24e, putative
Saccharomyces cerevisiae YGL031C   ribosomal 60S subunit protein L24A
Saccharomyces cerevisiae YGR148C   ribosomal 60S subunit protein L24B
Schistosoma japonicum Sjp_0044550   ko:K02896 large subunit ribosomal protein L24e, putative
Schistosoma mansoni Smp_001830.2   60S ribosomal protein L24
Schistosoma mansoni Smp_001830.1   60S ribosomal protein L24
Schmidtea mediterranea mk4.008385.00   60S ribosomal protein L24
Trypanosoma brucei gambiense Tbg972.10.6650   60S ribosomal protein L24, putative
Trypanosoma brucei gambiense Tbg972.10.6670   60S ribosomal protein L24, putative
Trypanosoma brucei Tb927.10.5460   60S ribosomal protein L24, putative
Trypanosoma brucei Tb927.10.5480   60S ribosomal protein L24, putative
Trypanosoma cruzi TcCLB.503611.20   ribosomal protein L24, putative
Trypanosoma cruzi TcCLB.506679.250   ribosomal protein L24, putative
Trypanosoma cruzi TcCLB.506679.230   ribosomal protein L24, putative
Trypanosoma cruzi TcCLB.503611.40   ribosomal protein L24, putative
Toxoplasma gondii TGME49_244320   ribosomal protein RPL24
Theileria parva TP03_0050   60S ribosomal protein L24, putative
Trichomonas vaginalis TVAG_101690   60S ribosomal protein L24, putative
Trichomonas vaginalis TVAG_431350   60S ribosomal protein L24, putative
Trichomonas vaginalis TVAG_190290   60S ribosomal protein L24, putative
Trichomonas vaginalis TVAG_324900   60S ribosomal protein L24, putative

Essentiality

Smp_001830.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5460 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.5460 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.5460 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.5460 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D1007.12 Caenorhabditis elegans embryonic lethal wormbase
CELE_D1007.12 Caenorhabditis elegans larval arrest wormbase
CELE_D1007.12 Caenorhabditis elegans slow growth wormbase
CELE_D1007.12 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_001830.1 (Schistosoma mansoni), 60S ribosomal protein L24
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