Detailed view for Smp_014400.1

Basic information

TDR Targets ID: 288139
Schistosoma mansoni, enhancer of polycomb
Source Database / ID:  GeneDB

pI: 8.3751 | Length (AA): 651 | MW (Da): 74039 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10513   Enhancer of polycomb-like

Gene Ontology

Mouse over links to read term descriptions.
GO:0035267   NuA4 histone acetyltransferase complex  
GO:0032777   Piccolo NuA4 histone acetyltransferase complex  
GO:0006357   regulation of transcription from RNA polymerase II promoter  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 186 4oy2 (B) 165 309 31.00 0.35 0.5 0.35264 1.02
236 321 4qns (A) 1370 1455 7.00 0.89 0 0.274804 -0.84

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128576)

Species Accession Gene Product
Arabidopsis thaliana AT1G79020   enhancer of polycomb-like transcription factor protein
Arabidopsis thaliana AT1G16690   Enhancer of polycomb-like transcription factor protein
Brugia malayi Bm1_28850   hypothetical protein
Candida albicans CaO19.7529   similar to S. cerevisiae EPL1 (YFL024C) NuA4 histone acetyltransferase complex component
Caenorhabditis elegans CELE_Y111B2A.11   Protein EPC-1
Dictyostelium discoideum DDB_G0287727   hypothetical protein
Drosophila melanogaster Dmel_CG7776   Enhancer of Polycomb
Echinococcus granulosus EgrG_000279300   enhancer of polycomb
Echinococcus granulosus EgrG_000824300   enhancer of polycomb
Echinococcus multilocularis EmuJ_000824300   enhancer of polycomb
Echinococcus multilocularis EmuJ_000279300   enhancer of polycomb
Homo sapiens ENSG00000120616   enhancer of polycomb homolog 1 (Drosophila)
Homo sapiens ENSG00000135999   enhancer of polycomb homolog 2 (Drosophila)
Loa Loa (eye worm) LOAG_03802   hypothetical protein
Mus musculus ENSMUSG00000069495   enhancer of polycomb homolog 2 (Drosophila)
Oryza sativa 4346622   Os09g0284600
Oryza sativa 4345317   Os08g0338900
Saccharomyces cerevisiae YFL024C   Epl1p
Schistosoma japonicum Sjp_0018430   Enhancer of polycomb homolog 1, putative
Schistosoma mansoni Smp_014400.6   enhancer of polycomb
Schistosoma mansoni Smp_014400.3   enhancer of polycomb
Schistosoma mansoni Smp_014400.1   enhancer of polycomb
Schistosoma mansoni Smp_014400.5   enhancer of polycomb
Schmidtea mediterranea mk4.015464.00   Enhancer of polycomb-like protein
Schmidtea mediterranea mk4.016367.00   Enhancer of polycomb-like protein

Essentiality

Smp_014400.1 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y111B2A.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y111B2A.11 Caenorhabditis elegans larval arrest wormbase
CELE_Y111B2A.11 Caenorhabditis elegans larval lethal wormbase
CELE_Y111B2A.11 Caenorhabditis elegans slow growth wormbase
YFL024C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_014400.1 (Schistosoma mansoni), enhancer of polycomb
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