Detailed view for Smp_043390

Basic information

TDR Targets ID: 288201
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 6.501 | Length (AA): 784 | MW (Da): 87205 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00933   Glycosyl hydrolase family 3 N terminal domain
PF01915   Glycosyl hydrolase family 3 C-terminal domain
PF14310   Fibronectin type III-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 761 5yot (A) 26 776 15.00 0.002 1 0.912478 0.72
34 758 3zyz (A) 14 707 20.00 0 1 1.01174 0.19
147 232 5wug (A) 665 747 37.00 0.000057 1 0.621894 -1.12
567 628 3wli (A) 559 600 38.00 0 0.06 -0.279918 2.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131698)

Species Accession Gene Product
Arabidopsis thaliana AT5G09700   Glycosyl hydrolase family protein
Arabidopsis thaliana AT5G49360   bifunctional {beta}-D-xylosidase/{alpha}-L-arabinofuranosidase
Arabidopsis thaliana AT1G02640   probable beta-D-xylosidase 2
Arabidopsis thaliana AT5G64570   beta-D-xylosidase 4
Arabidopsis thaliana AT5G09730   beta-xylosidase 3
Arabidopsis thaliana AT3G19620   putative beta-D-xylosidase 5
Arabidopsis thaliana AT5G10560   putative beta-D-xylosidase 6
Arabidopsis thaliana AT1G78060   putative beta-D-xylosidase 7
Echinococcus granulosus EgrG_000879900   beta D xylosidase 2
Echinococcus multilocularis EmuJ_000879900   beta D xylosidase 2
Oryza sativa 4350320   Os11g0297800
Oryza sativa 4330750   Os02g0752200
Oryza sativa 4351103   Os11g0673200
Oryza sativa 4350319   Os11g0297300
Oryza sativa 4351177   Os11g0696400
Oryza sativa 4336485   Os04g0530700
Oryza sativa 4350301   Os11g0291000
Oryza sativa 4337166   Os04g0640700
Schistosoma japonicum Sjp_0111210   Conserved hypothetical protein
Schistosoma japonicum Sjp_0106580   ko:K01188 beta-glucosidase [EC3.2.1.21], putative
Schistosoma mansoni Smp_043390   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0032 0.6015 0.6015

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_043390 (Schistosoma mansoni), hypothetical protein
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