pI: 5.1898 |
Length (AA): 1116 |
MW (Da): 128288 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
572 | 902 | 2zxe (A) | 456 | 745 | 27.00 | 0.000095 | 1 | 0.348995 | 1.09 |
723 | 760 | 4bbj (A) | 551 | 588 | 42.00 | 0.7 | 0.71 | 0.54645 | -0.3 |
833 | 922 | 2pq0 (A) | 164 | 257 | 27.00 | 0.75 | 0.16 | 0.0550452 | 1.43 |
869 | 922 | 5is2 (A) | 336 | 386 | 43.00 | 0.11 | 0.69 | 0.412787 | 0.76 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128792)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.2680 | Drs2 family of the P-type ATPase superfamily |
Candida albicans | CaO19.10195 | Drs2 family of the P-type ATPase superfamily |
Caenorhabditis elegans | CELE_W09D10.2 | Protein TAT-3 |
Cryptosporidium hominis | Chro.70206 | adenosinetriphosphatase 2 |
Drosophila melanogaster | Dmel_CG4301 | CG4301 gene product from transcript CG4301-RC |
Drosophila melanogaster | Dmel_CG33298 | CG33298 gene product from transcript CG33298-RB |
Echinococcus granulosus | EgrG_000911800 | phospholipid transporting atpase |
Echinococcus granulosus | EgrG_000911900 | phospholipid transporting ATPase VA |
Entamoeba histolytica | EHI_140130 | phospholipid-transporting P-type ATPase, putative |
Echinococcus multilocularis | EmuJ_000912000 | phospholipid transporting ATPase VB |
Echinococcus multilocularis | EmuJ_000911800 | phospholipid transporting atpase |
Echinococcus multilocularis | EmuJ_000911900 | phospholipid transporting ATPase VA |
Homo sapiens | ENSG00000118322 | ATPase, class V, type 10B |
Homo sapiens | 57194 | ATPase, class V, type 10A |
Homo sapiens | ENSG00000145246 | ATPase, class V, type 10D |
Mus musculus | ENSMUSG00000025324 | ATPase, class V, type 10A |
Mus musculus | ENSMUSG00000055415 | ATPase, class V, type 10B |
Mus musculus | ENSMUSG00000046808 | ATPase, class V, type 10D |
Saccharomyces cerevisiae | YMR162C | aminophospholipid-translocating P4-type ATPase DNF3 |
Schistosoma japonicum | Sjp_0107900 | Probable phospholipid-transporting ATPase VD, putative |
Schistosoma japonicum | Sjp_0110280 | Probable phospholipid-transporting ATPase VB, putative |
Schistosoma japonicum | Sjp_0055810 | Probable phospholipid-transporting ATPase VD, putative |
Schistosoma japonicum | Sjp_0084380 | ko:K01530 phospholipid-translocating ATPase [EC3.6.3.1], putative |
Schistosoma mansoni | Smp_181230 | phospholipid-transporting atpase |
Schmidtea mediterranea | mk4.001225.16 | |
Schmidtea mediterranea | mk4.004081.02 | |
Schmidtea mediterranea | mk4.005632.01 | |
Schmidtea mediterranea | mk4.000005.39 | |
Schmidtea mediterranea | mk4.001225.14 | Phospholipid-transporting atpase |
Schmidtea mediterranea | mk4.000005.37 | |
Schmidtea mediterranea | mk4.000512.02 | |
Schmidtea mediterranea | mk4.001225.13 | |
Schmidtea mediterranea | mk4.000005.40 | Phospholipid-transporting atpase |
Schmidtea mediterranea | mk4.000005.36 | |
Schmidtea mediterranea | mk4.000005.32 | Phospholipid-transporting atpase |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.