Detailed view for Smp_020080.2

Basic information

TDR Targets ID: 288469
Schistosoma mansoni, GTP-binding protein (I) alpha-1subunit gnai1
Source Database / ID:  GeneDB

pI: 5.2816 | Length (AA): 332 | MW (Da): 38167 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00503   G-protein alpha subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0031683   G-protein beta/gamma-subunit binding  
GO:0007188   G-protein signaling, coupled to cAMP nucleotide second messenger  
GO:0019001   guanyl nucleotide binding  
GO:0005525   GTP binding  
GO:0004871   signal transducer activity  
GO:0003924   GTPase activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  
GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 332 3v00 (C) 1 350 60.00 0 1 1.6094 -0.02
35 323 3c7k (A) 35 345 64.00 0 1 1.58508 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126802)

Species Accession Gene Product
Arabidopsis thaliana AT2G26300   guanine nucleotide-binding protein alpha-1 subunit
Brugia malayi Bm1_40550   guanine nucleotide-binding protein alpha-7 subunit, putative
Brugia malayi Bm1_35125   GTP-binding regulatory protein alpha chain - starfish, putative
Brugia malayi Bm1_51340   Guanine nucleotide-binding protein alpha-3 subunit, putative
Candida albicans CaO19.4015   likely G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone respon
Candida albicans CaO19.9189   similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase
Candida albicans CaO19.11498   G-protein alpha subunit capable of functional substitution for S. cerevisiae GPA1 (YHR005C) component of pheromone response path
Candida albicans CaO19.1621   similar to G-alpha protein, glucose-induced activation of plasma membrane ATPase
Caenorhabditis elegans CELE_R10H10.5   Protein GPA-7
Caenorhabditis elegans CELE_C34D1.3   Protein ODR-3
Caenorhabditis elegans CELE_C26C6.2   Protein GOA-1
Caenorhabditis elegans CELE_T07A9.7   Protein GPA-4
Caenorhabditis elegans CELE_Y95B8A.5   Protein GPA-16
Dictyostelium discoideum DDB_G0286185   G-protein subunit alpha 5
Dictyostelium discoideum DDB_G0285425   G-protein subunit alpha 4
Dictyostelium discoideum DDB_G0283151   G-protein subunit alpha 6
Dictyostelium discoideum DDB_G0276267   G-protein subunit alpha 2
Dictyostelium discoideum DDB_G0283349   G-protein subunit alpha 1
Drosophila melanogaster Dmel_CG2204   G protein alpha o subunit
Drosophila melanogaster Dmel_CG10060   G protein alpha i subunit
Echinococcus granulosus EgrG_000150800   gtp binding protein I alpha 1subunit
Echinococcus granulosus EgrG_001157600   guanine nucleotide binding protein G protein
Echinococcus granulosus EgrG_001157400   guanine nucleotide binding protein G protein
Entamoeba histolytica EHI_140350   G protein alpha subunit, putative
Echinococcus multilocularis EmuJ_001157400   guanine nucleotide binding protein (G protein)
Echinococcus multilocularis EmuJ_000150800   gtp binding protein (I) alpha 1subunit
Echinococcus multilocularis EmuJ_001157600   guanine nucleotide binding protein (G protein)
Homo sapiens ENSG00000134183   guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Homo sapiens 2773   guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Homo sapiens ENSG00000127955   guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Homo sapiens ENSG00000087258   guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Homo sapiens ENSG00000114353   guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Homo sapiens ENSG00000214415   guanine nucleotide binding protein, alpha transducing 3
Loa Loa (eye worm) LOAG_05154   GTP-binding regulatory protein alpha chain
Loa Loa (eye worm) LOAG_15095   hypothetical protein
Loa Loa (eye worm) LOAG_12372   heterotrimeric G protein alpha subunit
Loa Loa (eye worm) LOAG_04754   hypothetical protein
Loa Loa (eye worm) LOAG_13532   hypothetical protein
Loa Loa (eye worm) LOAG_15202   hypothetical protein
Mus musculus ENSMUSG00000031748   guanine nucleotide binding protein, alpha O
Mus musculus ENSMUSG00000057614   guanine nucleotide binding protein (G protein), alpha inhibiting 1
Mus musculus ENSMUSG00000000001   guanine nucleotide binding protein (G protein), alpha inhibiting 3
Mus musculus ENSMUSG00000028777   guanine nucleotide binding protein, alpha transducing 3
Mus musculus ENSMUSG00000009108   guanine nucleotide binding protein, alpha transducing 2
Mus musculus ENSMUSG00000032562   guanine nucleotide binding protein (G protein), alpha inhibiting 2
Oryza sativa 9272594   Os05g0341300
Oryza sativa 4338448   Os05g0333200
Saccharomyces cerevisiae YER020W   guanine nucleotide-binding protein subunit alpha
Saccharomyces cerevisiae YHR005C   guanine nucleotide-binding protein subunit alpha
Schistosoma japonicum Sjp_0019060   Guanine nucleotide-binding protein G(i) subunit alpha, putative
Schistosoma japonicum Sjp_0095470   Guanine nucleotide-binding protein G(i) subunit alpha, putative
Schistosoma japonicum Sjp_0213070   Guanine nucleotide-binding protein G(i) subunit alpha-1, putative
Schistosoma japonicum Sjp_0083810   Guanine nucleotide-binding protein G(i) subunit alpha, putative
Schistosoma japonicum Sjp_0122040   Guanine nucleotide-binding protein G(i) subunit alpha, putative
Schistosoma japonicum Sjp_0037230   ko:K04534 guanine nucleotide binding protein (G protein), alpha o polypeptide, putative
Schistosoma mansoni Smp_016250.1   GTP-binding protein (I) alpha-2 subunit gnai2
Schistosoma mansoni Smp_016250.2   GTP-binding protein (I) alpha-2 subunit gnai2
Schistosoma mansoni Smp_016630.1   trimeric G-protein alpha o subunit
Schistosoma mansoni Smp_020080.1   GTP-binding protein (I) alpha-1subunit gnai1
Schistosoma mansoni Smp_020080.2   GTP-binding protein (I) alpha-1subunit gnai1
Schmidtea mediterranea mk4.003615.00  
Schmidtea mediterranea mk4.006953.01  
Schmidtea mediterranea mk4.016832.00  
Schmidtea mediterranea mk4.000771.04   Guanine nucleotide-binding protein alpha-6 subunit
Schmidtea mediterranea mk4.001031.01   G protein alpha subunit
Schmidtea mediterranea mk4.003887.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.005884.02   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.021023.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.019448.00  
Schmidtea mediterranea mk4.011166.02   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.006693.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.003497.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.018021.00  
Schmidtea mediterranea mk4.024017.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.002436.06   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.001937.01   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.010700.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.000897.11  
Schmidtea mediterranea mk4.000560.06  
Schmidtea mediterranea mk4.009212.00  
Schmidtea mediterranea mk4.000714.01  
Schmidtea mediterranea mk4.006273.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.023438.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.011317.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000051.08   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.055596.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.003888.03   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.005746.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.028183.00  
Schmidtea mediterranea mk4.027187.00  
Schmidtea mediterranea mk4.005711.01   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000662.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.028708.00   Guanine nucleotide-binding protein alpha-16 subunit
Schmidtea mediterranea mk4.000333.14   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.012788.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000081.08   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.013406.02  
Schmidtea mediterranea mk4.007734.02   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000909.03  
Schmidtea mediterranea mk4.013497.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.002824.04   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.004230.01   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000227.11   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.005704.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000153.24   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.006081.01   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.019114.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.033715.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.006197.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.005729.01   Guanine nucleotide-binding protein alpha-16 subunit
Schmidtea mediterranea mk4.000945.00  
Schmidtea mediterranea mk4.006902.00  
Schmidtea mediterranea mk4.000771.06  
Schmidtea mediterranea mk4.002579.08   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.000084.22   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.003185.00  
Schmidtea mediterranea mk4.013844.00   Guanine nucleotide-binding protein alpha-16 subunit
Schmidtea mediterranea mk4.005729.00  
Schmidtea mediterranea mk4.008543.00  
Schmidtea mediterranea mk4.001070.01  
Schmidtea mediterranea mk4.000891.10  
Schmidtea mediterranea mk4.023505.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.005775.04   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.008305.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.017355.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.009732.02  
Schmidtea mediterranea mk4.002844.03  
Schmidtea mediterranea mk4.003960.01   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.012375.01  
Schmidtea mediterranea mk4.000051.09   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.006445.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.047130.00   Guanine nucleotide-binding protein alpha-16 subunit
Schmidtea mediterranea mk4.005979.02  
Schmidtea mediterranea mk4.025460.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000153.20   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.000016.04   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.001836.00  
Schmidtea mediterranea mk4.023096.02  
Schmidtea mediterranea mk4.003234.04  
Schmidtea mediterranea mk4.026945.02   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.021322.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000208.05   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.001220.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.005708.03   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.007547.00  
Schmidtea mediterranea mk4.001122.00   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.004663.01   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.021135.00   Putative gtp-binding protein
Schmidtea mediterranea mk4.003329.05   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.000704.05   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000026.24   Putative trimeric G-protein alpha o subunit
Schmidtea mediterranea mk4.000020.05   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.001155.06  
Schmidtea mediterranea mk4.020928.00   Guanine nucleotide-binding protein G(o) subunit alpha
Schmidtea mediterranea mk4.000159.13  
Trichomonas vaginalis TVAG_374970   GTP-binding protein (z) alpha subunit, gnaz, putative
Trichomonas vaginalis TVAG_490430   G protein (olf) alpha subunit, gnal, putative
Trichomonas vaginalis TVAG_274750   GTP-binding protein alpha subunit, gna, putative
Trichomonas vaginalis TVAG_452120   GTP-binding protein alpha subunit, gna, putative

Essentiality

Smp_020080.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C26C6.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C26C6.2 Caenorhabditis elegans larval arrest wormbase
CELE_Y95B8A.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y95B8A.5 Caenorhabditis elegans sterile wormbase
YHR005C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O Compounds References
Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0014 1 0.5
0.0029 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_020080.2 (Schistosoma mansoni), GTP-binding protein (I) alpha-1subunit gnai1
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