Detailed view for Smp_175780

Basic information

TDR Targets ID: 288524
Schistosoma mansoni, sex-determining protein fem-1
Source Database / ID:  GeneDB

pI: 7.6255 | Length (AA): 1138 | MW (Da): 128312 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12796   Ankyrin repeats (3 copies)
PF13606   Ankyrin repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 18 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 108 5u0k (A) 486 572 34.00 0.12 1 0.495359 -0.82
15 271 5jhq (A) 184 457 28.00 0.000000012 1 0.416835 0.28
15 190 6aun (A) 187 385 26.00 0.000001 1 0.378657 -0.05
37 174 4k5c (A) 37 179 33.00 0.00000000051 1 0.601265 -1.11
37 256 5y4f (A) 618 829 29.00 0 1 0.599322 -0.67
46 174 1ymp (A) 117 236 30.00 0.1 1 0.512357 -0.8
47 146 1n0q (A) 2 92 45.00 0.00000000025 1 0.613873 -0.77
84 182 4hrm (D) 15 140 42.00 0.00000094 1 0.616995 -0.91
89 212 1n0r (A) 2 125 37.00 0 1 0.655263 -1.58
92 205 3aaa (C) 5 118 31.00 0 1 0.588476 -1.6
92 445 6fes (A) 17 372 18.00 0 1 0.448372 -0.09
111 239 1ymp (A) 107 236 21.00 0 1 0.429857 -0.96
122 210 5u0i (A) 553 642 17.00 0 1 0.413507 -1.58
124 194 5czy (A) 336 415 39.00 0.042 1 0.43039 -0.69
124 209 2xen (A) 16 101 30.00 0 1 0.569871 -1.76
975 1099 4atz (D) 18 135 22.00 0 0.79 0.244742 -0.03
978 1097 4jb8 (P) 21 133 19.00 0 0.44 0.194348 -0.32
1008 1092 2b0o (E) 590 670 16.00 0.00071 0.12 -0.0194076 0.49

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131733)

Species Accession Gene Product
Brugia malayi Bm1_31565   Sex-determining protein fem-1
Caenorhabditis elegans CELE_F35D6.1   Protein FEM-1, isoform B
Drosophila melanogaster Dmel_CG6966   CG6966 gene product from transcript CG6966-RC
Echinococcus granulosus EgrG_001103800   sex determining protein fem 1
Echinococcus multilocularis EmuJ_001103800   sex determining protein fem 1
Homo sapiens ENSG00000145780   fem-1 homolog c (C. elegans)
Homo sapiens 55527   fem-1 homolog a (C. elegans)
Loa Loa (eye worm) LOAG_08090   sex-determining protein fem-1
Mus musculus ENSMUSG00000043683   feminization 1 homolog a (C. elegans)
Mus musculus 240263   fem-1 homolog c (C.elegans)
Mus musculus ENSMUSG00000078157   RIKEN cDNA 4931440F15 gene
Schistosoma japonicum Sjp_0002660   Protein fem-1 homolog CG6966, putative
Schistosoma mansoni Smp_175780   sex-determining protein fem-1
Schmidtea mediterranea mk4.006043.01   Sex-determining protein fem-1
Schmidtea mediterranea mk4.019935.02   Sex-determining protein fem-1
Schmidtea mediterranea mk4.019935.00   Sex-determining protein fem-1
Schmidtea mediterranea mk4.010794.02   Sex-determining protein fem-1
Schmidtea mediterranea mk4.010794.00   Sex-determining protein fem-1

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_175780 (Schistosoma mansoni), sex-determining protein fem-1
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