Detailed view for Smp_060420.5

Basic information

TDR Targets ID: 288820
Schistosoma mansoni, suppressor of actin (sac)
Source Database / ID:  GeneDB

pI: 8.4884 | Length (AA): 620 | MW (Da): 70787 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02383   SacI homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042578   phosphoric ester hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
45 505 3lwt (X) 47 456 32.00 0 1 0.944248 0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127875)

Species Accession Gene Product
Arabidopsis thaliana AT3G51830   putative transmembrane protein G5p
Arabidopsis thaliana AT5G66020   phosphoinositide phosphatase SAC6
Arabidopsis thaliana AT3G51460   phosphatidylinositol-4-phosphate phosphatase RHD4
Candida albicans CaO19.4865   Polyphosphoinositide phosphatase, suppressor of actin mutations
Candida albicans CaO19.12329   Polyphosphoinositide phosphatase, suppressor of actin mutations
Caenorhabditis elegans CELE_F30A10.6   Protein SAC-1
Cryptosporidium hominis Chro.40021   hypothetical protein
Cryptosporidium parvum cgd4_80   Sac1p family protein
Dictyostelium discoideum DDB_G0290653   hypothetical protein
Dictyostelium discoideum DDB_G0271630   hypothetical protein
Drosophila melanogaster Dmel_CG9128   CG9128 gene product from transcript CG9128-RB
Echinococcus granulosus EgrG_001151400   phosphatidylinositide phosphatase sac1
Entamoeba histolytica EHI_048570   phosphoinositide phosphatase, putative
Entamoeba histolytica EHI_141860   phosphoinositide phosphatase, putative
Echinococcus multilocularis EmuJ_001151400   phosphatidylinositide phosphatase sac1
Giardia lamblia GL50803_8589   Suppressor of actin 1
Homo sapiens ENSG00000211456   SAC1 suppressor of actin mutations 1-like (yeast)
Loa Loa (eye worm) LOAG_08188   hypothetical protein
Mus musculus ENSMUSG00000025240   SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)
Neospora caninum NCLIV_058740   hypothetical protein
Oryza sativa 4332501   Os03g0290500
Oryza sativa 4350352   Os11g0309000
Oryza sativa 4329650   Os02g0554300
Plasmodium berghei PBANKA_1130800   inositol-polyphosphate 5-phosphatase, putative
Plasmodium falciparum PF3D7_1354200   inositol-polyphosphate 5-phosphatase, putative
Plasmodium knowlesi PKNH_1117600   inositol-polyphosphate 5-phosphatase, putative
Plasmodium vivax PVX_114695   phosphoinositide phosphatase SAC1, putative
Plasmodium yoelii PY02348   Homo sapiens KIAA0851 protein-related
Saccharomyces cerevisiae YKL212W   phosphatidylinositol-3-phosphatase SAC1
Schistosoma japonicum Sjp_0108180   Phosphatidylinositide phosphatase SAC1-A, putative
Schistosoma mansoni Smp_060420.5   suppressor of actin (sac)
Schistosoma mansoni Smp_060420.4   suppressor of actin (sac)
Schistosoma mansoni Smp_060420.3   suppressor of actin (sac)
Schmidtea mediterranea mk4.000924.02   Putative suppressor of actin
Toxoplasma gondii TGME49_316230   SAC1 phosphoinositide phosphatase, putative
Trichomonas vaginalis TVAG_312090   synaptojanin, putative

Essentiality

Smp_060420.5 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F30A10.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_F30A10.6 Caenorhabditis elegans larval arrest wormbase
CELE_F30A10.6 Caenorhabditis elegans slow growth wormbase
TGME49_316230 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_060420.5 (Schistosoma mansoni), suppressor of actin (sac)
Title for this comment
Comment