pI: 5.2781 |
Length (AA): 347 |
MW (Da): 37517 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 346 | 6g4q (B) | 61 | 462 | 41.00 | 0 | 1 | 1.29782 | 0.65 |
1 | 346 | 6g4q (B) | 61 | 462 | 61.00 | 0 | 1 | 1.34142 | 0.26 |
199 | 327 | 2yv1 (A) | 150 | 291 | 16.00 | 0 | 0.79 | 0.593258 | -0.63 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126862)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G20420 | Succinyl-CoA ligase [GDP-forming] subunit beta |
Babesia bovis | BBOV_IV010490 | succinly CoA-ligase beta subunit, putative |
Brugia malayi | Bm1_00840 | succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial |
Candida albicans | CaO19.710 | similar to C terminus of S. cerevisiae LSC2 (YGR244C) succinyl-CoA synthetase beta-subunit |
Candida albicans | CaO19.8329 | similar to C terminus of S. cerevisiae LSC2 (YGR244C) succinyl-CoA synthetase beta-subunit |
Caenorhabditis elegans | CELE_C50F7.4 | Protein SUCG-1 |
Caenorhabditis elegans | CELE_F47B10.1 | Protein SUCA-1 |
Chlamydia trachomatis | CT_821 | succinyl-CoA ligase subunit beta |
Dictyostelium discoideum | DDB_G0274449 | GTP-specific succinyl-CoA synthetase beta subunit |
Dictyostelium discoideum | DDB_G0271842 | ATP-specific succinyl-CoA synthetase beta subunit |
Drosophila melanogaster | Dmel_CG11963 | skpA associated protein |
Drosophila melanogaster | Dmel_CG10622 | CG10622 gene product from transcript CG10622-RA |
Escherichia coli | b0728 | succinyl-CoA synthetase, beta subunit |
Echinococcus granulosus | EgrG_000519200 | succinyl coenzyme A ligase ADP forming subunit beta |
Echinococcus granulosus | EgrG_000818100 | succinyl coenzyme A ligase GDP forming subunit beta |
Echinococcus multilocularis | EmuJ_000818100 | succinyl coenzyme A ligase (GDP forming) subunit beta |
Echinococcus multilocularis | EmuJ_000519200 | succinyl coenzyme A ligase (ADP forming) subunit beta |
Homo sapiens | ENSG00000172340 | succinate-CoA ligase, GDP-forming, beta subunit |
Homo sapiens | ENSG00000136143 | succinate-CoA ligase, ADP-forming, beta subunit |
Leishmania braziliensis | LbrM.35.3170 | succinyl-CoA ligase [GDP-forming] beta-chain, putative;with=GeneDB:LmjF36.2950 |
Leishmania donovani | LdBPK_363100.1 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Leishmania infantum | LinJ.36.3100 | succinyl-CoA ligase [GDP-forming] beta-chain, putative;with=GeneDB:LmjF36.2950 |
Leishmania major | LmjF.36.2950 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Leishmania mexicana | LmxM.36.2950 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Loa Loa (eye worm) | LOAG_13194 | succinate-CoA ligase |
Loa Loa (eye worm) | LOAG_09172 | hypothetical protein |
Mycobacterium leprae | ML0155 | Probable succinyl-CoA synthase, (beta chain) SucC (SCS-beta) |
Mus musculus | ENSMUSG00000022110 | succinate-Coenzyme A ligase, ADP-forming, beta subunit |
Mus musculus | ENSMUSG00000061838 | succinate-Coenzyme A ligase, GDP-forming, beta subunit |
Mycobacterium tuberculosis | Rv0951 | Probable succinyl-CoA synthetase (beta chain) SucC (SCS-beta) |
Mycobacterium ulcerans | MUL_4720 | succinyl-CoA synthetase subunit beta |
Neospora caninum | NCLIV_053880 | cDNA FLJ54097, highly similar to Succinyl-CoA ligase (ADP-forming) beta-chain, mitochondrial (EC 6.2.1.5), related |
Oryza sativa | 4330016 | Os02g0621700 |
Onchocerca volvulus | OVOC1752 |
|
Plasmodium berghei | PBANKA_1013200 | succinyl-CoA ligase [ADP-forming] subunit beta, putative |
Plasmodium falciparum | PF3D7_1431600 | succinyl-CoA ligase [ADP-forming] subunit beta, putative |
Plasmodium knowlesi | PKNH_1327100 | succinyl-CoA ligase [ADP-forming] subunit beta, putative |
Plasmodium vivax | PVX_084960 | ATP-specific succinyl-CoA synthetase beta subunit, putative |
Plasmodium yoelii | PY02175 | succinyl-coa ligase beta-chain, hydrogenosomal precursor |
Saccharomyces cerevisiae | YGR244C | succinate--CoA ligase (GDP-forming) subunit beta |
Schistosoma japonicum | Sjp_0017100 | ko:K01898 succinate--CoA ligase (GDP-forming) [EC6.2.1.4], putative |
Schistosoma japonicum | Sjp_0111950 | ko:K01903 succinyl-CoA synthetase beta chain [EC6.2.1.5B], putative |
Schistosoma mansoni | Smp_060820 | succinyl-CoA synthetase beta chain |
Schistosoma mansoni | Smp_167330 | succinyl-CoA synthetase beta chain |
Schmidtea mediterranea | mk4.002918.02 | |
Schmidtea mediterranea | mk4.002918.01 | Putative succinyl-CoA synthetase beta chain |
Schmidtea mediterranea | mk4.028028.01 | Succinyl-CoA ligase |
Schmidtea mediterranea | mk4.058520.00 | |
Schmidtea mediterranea | mk4.006545.00 | Putative succinyl-CoA synthetase beta chain |
Schmidtea mediterranea | mk4.013183.01 | Succinyl-CoA ligase |
Schmidtea mediterranea | mk4.002918.03 | Probable succinyl-CoA ligase |
Schmidtea mediterranea | mk4.006770.01 | Succinyl-CoA ligase |
Schmidtea mediterranea | mk4.028028.00 | |
Schmidtea mediterranea | mk4.013183.00 | Succinyl-CoA ligase |
Trypanosoma brucei gambiense | Tbg972.10.9090 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Trypanosoma brucei | Tb927.10.7410 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Trypanosoma cruzi | TcCLB.507681.20 | succinyl-CoA ligase [GDP-forming] beta-chain, putative |
Toxoplasma gondii | TGME49_309752 | succinate-Coenzyme A ligase, beta subunit, putative |
Theileria parva | TP01_0677 | ATP-specific succinyl-CoA synthetase beta subunit, putative |
Trichomonas vaginalis | TVAG_259190 | succinate thiokinase, beta subunit |
Trichomonas vaginalis | TVAG_183500 | succinate thiokinase, beta subunit |
Trichomonas vaginalis | TVAG_144730 | succinate thiokinase, beta subunit |
Wolbachia endosymbiont of Brugia malayi | Wbm0520 | succinyl-CoA synthetase subunit beta |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu966 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.7410 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7410 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7410 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.7410 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0728 | Escherichia coli | non-essential | goodall |
CELE_C50F7.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
YGR244C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_309752 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.