pI: 7.6176 |
Length (AA): 678 |
MW (Da): 73942 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_130178)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G13770 | hypothetical protein |
Brugia malayi | Bm1_23850 | cDNA sequence BC017158 |
Dictyostelium discoideum | DDB_G0277179 | DUF647 family protein |
Drosophila melanogaster | Dmel_CG10338 | CG10338 gene product from transcript CG10338-RB |
Echinococcus granulosus | EgrG_001194500 | protein of unknown function DUF647 |
Entamoeba histolytica | EHI_149730 | hypothetical protein, conserved |
Echinococcus multilocularis | EmuJ_001194500 | protein of unknown function DUF647 |
Homo sapiens | ENSG00000140688 | chromosome 16 open reading frame 58 |
Leishmania donovani | LdBPK_211770.1 | Vitamin B6 photo-protection and homoeostasis, putative |
Leishmania infantum | LinJ.21.1770 | hypothetical protein, conserved |
Leishmania major | LmjF.21.1530 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.21.1530 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_07840 | hypothetical protein |
Mus musculus | ENSMUSG00000030780 | cDNA sequence BC017158 |
Oryza sativa | 9266565 | Os03g0213700 |
Onchocerca volvulus | OVOC10358 | UPF0420 protein C16orf58 homolog |
Onchocerca volvulus | OVOC12578 |
|
Schistosoma japonicum | Sjp_0090790 | similar to UPF0420 protein C16orf58, putative |
Schistosoma mansoni | Smp_142110 | hypothetical protein |
Schmidtea mediterranea | mk4.013079.00 | |
Schmidtea mediterranea | mk4.022617.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.