Detailed view for Smp_158500

Basic information

TDR Targets ID: 289240
Schistosoma mansoni, Mername-AA168 protein (M67 family)
Source Database / ID:  GeneDB

pI: 5.9598 | Length (AA): 850 | MW (Da): 94551 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01398   JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PF01423   LSM domain
PF04193   PQ loop repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005852   eukaryotic translation initiation factor 3 complex  
GO:0005737   cytoplasm  
GO:0005515   protein binding  
GO:0003743   translation initiation factor activity  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
337 401 1h64 (1) 12 71 25.00 0 0.96 0.368071 -0.48
339 402 4emh (A) 12 71 35.00 0.66 1 0.551594 -0.95
507 649 6fjv (A) 0 139 22.00 0 1 0.450835 -0.82
511 664 2o95 (A) 7 162 25.00 0.00082 0.98 0.576876 -0.97
553 849 4n5a (A) 17 329 12.00 0 0.02 0.406012 -0.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129149)

Species Accession Gene Product
Arabidopsis thaliana AT1G10840   translation initiation factor 3 subunit H1
Babesia bovis BBOV_III006660   conserved hypothetical protein
Brugia malayi Bm1_50170   Mov34/MPN/PAD-1 family protein
Candida albicans CaO19.6748   similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05
Candida albicans CaO19.14040   similar to human translation initiation factor eIF3-gamma-p40 subunit and to S. pombe SPAC821.05
Caenorhabditis elegans CELE_C41D11.2   Protein EIF-3.H
Cryptosporidium hominis Chro.70578   hypothetical protein
Cryptosporidium parvum cgd7_5180   eIF3 gamma/P40 with JAB/PAD domains; translation initiation factor IF-3 subunit 3
Dictyostelium discoideum DDB_G0281153   Mov34/MPN/PAD-1 family protein
Drosophila melanogaster Dmel_CG9124   Eukaryotic initiation factor 3 p40 subunit
Echinococcus granulosus EgrG_000260300   Mername AA168 protein M67 family
Echinococcus granulosus EgrG_000260200   PQ loop repeat containing protein 2
Echinococcus granulosus EgrG_000117100   eukaryotic translation initiation factor 3
Echinococcus multilocularis EmuJ_000260300   Mername AA168 protein (M67 family)
Echinococcus multilocularis EmuJ_000260200   PQ loop repeat containing protein 2
Echinococcus multilocularis EmuJ_000117100   eukaryotic translation initiation factor 3
Homo sapiens ENSG00000147677   eukaryotic translation initiation factor 3, subunit H
Loa Loa (eye worm) LOAG_06470   Mov34/MPN/PAD-1 family protein
Mus musculus ENSMUSG00000022312   eukaryotic translation initiation factor 3, subunit H
Neospora caninum NCLIV_066600   DEHA2F06798p, related
Oryza sativa 4335611   Os04g0376500
Schistosoma japonicum Sjp_0216630   PQ-loop repeat-containing protein 2, putative
Schistosoma japonicum Sjp_0305560   IPR010920,Like-Sm ribonucleoprotein-related, core;IPR001163,Like-Sm ribonucleoprotein, core,domain-containing
Schistosoma japonicum Sjp_0209430   ko:K03247 translation initiation factor eIF-3 subunit 3, putative
Schistosoma mansoni Smp_158500   Mername-AA168 protein (M67 family)
Schmidtea mediterranea mk4.009227.00   Eukaryotic translation initiation factor 3 subunit H
Schmidtea mediterranea mk4.002107.01   Eukaryotic translation initiation factor 3 subunit H
Toxoplasma gondii TGME49_251500   eukaryotic initiation factor-3, subunit 3, putative
Theileria parva TP02_0307   hypothetical protein
Trichomonas vaginalis TVAG_105990   eukaryotic translation initiation factor 3 subunit, putative

Essentiality

Smp_158500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C41D11.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_C41D11.2 Caenorhabditis elegans larval lethal wormbase
CELE_C41D11.2 Caenorhabditis elegans slow growth wormbase
TGME49_251500 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_158500 (Schistosoma mansoni), Mername-AA168 protein (M67 family)
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