Detailed view for Smp_033010

Basic information

TDR Targets ID: 289320
Schistosoma mansoni, calmodulin
Source Database / ID:  GeneDB

pI: 7.8099 | Length (AA): 145 | MW (Da): 17096 | Paralog Number: 6

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13499   EF-hand domain pair

Gene Ontology

Mouse over links to read term descriptions.
GO:0005509   calcium ion binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 144 1top (A) 13 161 26.00 0 1 1.3632 -0.7
3 145 5e37 (A) 24 177 31.00 0.0000000066 1 1.37001 -0.57
43 116 6fie (B) 146 228 41.00 0.23 0.78 0.697145 0.48
77 139 3e3r (A) 7 84 41.00 0.013 1 0.888283 -1.17
77 144 2m97 (A) 1 68 24.00 0.06 1 1.03377 -2.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138841)

Species Accession Gene Product
Echinococcus granulosus EgrG_000460300   16 kda calcium binding protein
Echinococcus granulosus EgrG_000460000   calmodulin
Echinococcus granulosus EgrG_000500300   Calcium binding protein
Echinococcus granulosus EgrG_000504500   Calcium binding protein
Echinococcus granulosus EgrG_000504400   16 kda calcium binding protein
Echinococcus granulosus EgrG_000460100   Calcium binding protein
Echinococcus granulosus EgrG_000459800   Calcium binding protein
Entamoeba histolytica EHI_173470   EF-hand calcium-binding domain containing protein
Echinococcus multilocularis EmuJ_000460000   calmodulin
Echinococcus multilocularis EmuJ_000460100   Calcium binding protein
Echinococcus multilocularis EmuJ_000504400   16 kda calcium binding protein
Echinococcus multilocularis EmuJ_000459800   Calcium binding protein
Echinococcus multilocularis EmuJ_000460300   16 kda calcium binding protein
Echinococcus multilocularis EmuJ_000504500   Calcium binding protein
Echinococcus multilocularis EmuJ_000500300   Calcium binding protein
Schistosoma japonicum Sjp_0013820   similar to 16 kDa calcium-binding protein, putative
Schistosoma japonicum Sjp_0087380   IPR002048,Calcium-binding EF-hand;IPR002160,Proteinase inhibitor I3, Kunitz legume,domain-containing
Schistosoma japonicum Sjp_0306900   similar to 16 kDa calcium-binding protein, putative
Schistosoma japonicum Sjp_0079410   IPR002048,Calcium-binding EF-hand,domain-containing
Schistosoma japonicum Sjp_0130880   IPR002048,Calcium-binding EF-hand,domain-containing
Schistosoma japonicum Sjp_0115600   similar to 16 kDa calcium-binding protein, putative
Schistosoma japonicum Sjp_0217410   similar to 16 kDa calcium-binding protein, putative
Schistosoma mansoni Smp_135980   calcium-binding protein
Schistosoma mansoni Smp_096410.2   calmodulin
Schistosoma mansoni Smp_033010   calmodulin
Schistosoma mansoni Smp_096390   calcium-binding protein
Schistosoma mansoni Smp_025410   calmodulin
Schistosoma mansoni Smp_025380   calmodulin
Schistosoma mansoni Smp_096410.1   calmodulin
Schmidtea mediterranea mk4.001687.02  
Schmidtea mediterranea mk4.000007.10  
Schmidtea mediterranea mk4.004156.04  
Schmidtea mediterranea mk4.002234.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_033010 (Schistosoma mansoni), calmodulin
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