pI: 5.9659 |
Length (AA): 218 |
MW (Da): 24167 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
13 | 209 | 2jj2 (G) | 25 | 240 | 51.00 | 0 | 0.94 | 0.50757 | 2.11 |
13 | 209 | 3oee (Y) | 25 | 245 | 37.00 | 0 | 1 | 0.89957 | 1.05 |
18 | 209 | 3zia (G) | 51 | 245 | 34.00 | 0 | 0.87 | 1.22103 | 0.07 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127077)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G33040 | ATP synthase subunit gamma |
Arabidopsis thaliana | AT1G15700 | ATP synthase gamma chain 2 |
Arabidopsis thaliana | AT4G04640 | ATP synthase gamma chain 1 |
Babesia bovis | BBOV_IV005350 | ATP synthase F1 gamma subunit, putative |
Brugia malayi | Bm1_13335 | ATP synthase gamma chain, mitochondrial precursor, putative |
Candida albicans | CaO19.3223 | allele is intact |
Candida albicans | CaO19.10734 | likely ATP synthase similar to S. cerevisiae ATP3 (YBR039W) gamma subunit of F1-ATP synthase |
Caenorhabditis elegans | CELE_Y69A2AR.18 | Protein Y69A2AR.18, isoform C |
Dictyostelium discoideum | DDB_G0292306 | ATP synthase gamma chain |
Drosophila melanogaster | Dmel_CG7610 | ATP synthase-gamma chain |
Escherichia coli | b3733 | F1 sector of membrane-bound ATP synthase, gamma subunit |
Echinococcus granulosus | EgrG_000115600 | ATP synthase gamma subunit |
Echinococcus multilocularis | EmuJ_000115600 | ATP synthase gamma subunit |
Homo sapiens | ENSG00000165629 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
Leishmania braziliensis | LbrM.33.0830 | ATP synthase F1 subunit gamma protein |
Leishmania donovani | LdBPK_212140.1 | ATP synthase F1 subunit gamma protein, putative |
Leishmania infantum | LinJ.21.2140 | ATP synthase F1 subunit gamma protein, putative |
Leishmania major | LmjF.21.1770 | ATP synthase F1 subunit gamma protein, putative |
Leishmania mexicana | LmxM.21.1770 | ATP synthase F1 subunit gamma protein, putative |
Loa Loa (eye worm) | LOAG_09256 | hypothetical protein |
Mycobacterium leprae | ML1144 | PROBABLE ATP SYNTHASE GAMMA CHAIN ATPG |
Mus musculus | ENSMUSG00000025781 | ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
Mycobacterium tuberculosis | Rv1309 | Probable ATP synthase gamma chain AtpG |
Mycobacterium ulcerans | MUL_3955 | F0F1 ATP synthase subunit gamma |
Neospora caninum | NCLIV_031920 | ATP synthase gama chain, putative |
Oryza sativa | 4348305 | Os10g0320400 |
Oryza sativa | 4343366 | Os07g0513000 |
Onchocerca volvulus | OVOC11295 | ATP synthase subunit gamma, mitochondrial homolog |
Plasmodium berghei | PBANKA_1409800 | ATP synthase subunit gamma, mitochondrial, putative |
Plasmodium falciparum | PF3D7_1311300 | ATP synthase subunit gamma, mitochondrial |
Plasmodium knowlesi | PKNH_1411700 | ATP synthase subunit gamma, mitochondrial, putative |
Plasmodium vivax | PVX_122395 | ATP synthase subunit gamma, mitochondrial, putative |
Plasmodium yoelii | PY02803 | ATP synthase F1, gamma subunit |
Saccharomyces cerevisiae | YBR039W | F1F0 ATP synthase subunit gamma |
Schistosoma japonicum | Sjp_0211820 | ko:K02136 F-type H+-transporting ATPase gamma chain, putative |
Schistosoma mansoni | Smp_033670.1 | ATP synthase gamma subunit |
Schistosoma mansoni | Smp_033670.5 | ATP synthase gamma subunit |
Schistosoma mansoni | Smp_033670.2 | ATP synthase gamma subunit |
Schistosoma mansoni | Smp_033670.3 | ATP synthase gamma subunit |
Schistosoma mansoni | Smp_033670.4 | ATP synthase gamma subunit |
Schmidtea mediterranea | mk4.000187.03 | ATP synthase gamma subunit, putative |
Trypanosoma brucei gambiense | Tbg972.10.90 | ATP synthase F1 subunit gamma protein, putative |
Trypanosoma brucei | Tb927.10.180 | ATP synthase F1 subunit gamma protein, putative |
Trypanosoma congolense | TcIL3000_10_50 | ATP synthase F1 subunit gamma protein, putative |
Trypanosoma cruzi | TcCLB.504069.80 | ATP synthase F1 subunit gamma protein, putative |
Trypanosoma cruzi | TcCLB.511145.60 | ATP synthase F1 subunit gamma protein, putative |
Toxoplasma gondii | TGME49_231910 | ATP synthase F1 gamma subunit |
Theileria parva | TP01_0201 | ATP synthase F1, gamma chain, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0705 | ATP synthase F0F1 subunit gamma |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1331 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.180 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.180 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.180 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3733 | Escherichia coli | non-essential | goodall |
CELE_Y69A2AR.18 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1409800 | Plasmodium berghei | Slow | plasmo |
TGME49_231910 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium tuberculosis | Probable ATP synthase gamma chain AtpG | Compounds | References |