pI: 4.8127 |
Length (AA): 246 |
MW (Da): 27662 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 245 | 5le2 (A) | 249 | 491 | 21.00 | 0 | 1 | 1.33873 | -0.5 |
141 | 231 | 2p2c (P) | 32 | 124 | 48.00 | 0 | 1 | 1.02572 | -1.04 |
152 | 241 | 3c5r (A) | 0 | 513 | 31.00 | 0 | 1 | 0.948454 | -1.86 |
187 | 242 | 2v5q (C) | 12 | 67 | 25.00 | 0 | 0.98 | 0.678242 | -1.16 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130105)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G53470 | acyl-CoA binding protein 1 |
Arabidopsis thaliana | AT4G27780 | acyl-CoA binding protein 2 |
Babesia bovis | BBOV_IV010810 | ankyrin repeat containing protein |
Brugia malayi | Bm1_13745 | BolA-like protein |
Caenorhabditis elegans | CELE_T12D8.3 | Protein ACBP-5 |
Cryptosporidium hominis | Chro.10136 | similar to proteasome 26S subunit, non-ATPase, 10-related |
Cryptosporidium parvum | cgd1_1140 | conserved hypothetical protein |
Dictyostelium discoideum | DDB_G0290237 | acyl-CoA binding protein |
Drosophila melanogaster | Dmel_CG33713 | CG33713 gene product from transcript CG33713-RA |
Echinococcus granulosus | EgrG_000127700 | acyl coenzyme A binding domain containing protein |
Echinococcus multilocularis | EmuJ_000127700 | acyl coenzyme A binding domain containing protein |
Homo sapiens | ENSG00000230124 | acyl-CoA binding domain containing 6 |
Loa Loa (eye worm) | LOAG_02855 | hypothetical protein |
Mus musculus | ENSMUSG00000033701 | acyl-Coenzyme A binding domain containing 6 |
Oryza sativa | 4337434 | Os04g0681900 |
Plasmodium berghei | PBANKA_0929100 | acyl-CoA-binding protein, putative |
Plasmodium falciparum | PF3D7_1119000 | acyl-CoA-binding protein, putative |
Plasmodium knowlesi | PKNH_0916700 | acyl-CoA-binding protein, putative |
Plasmodium vivax | PVX_091585 | acyl-CoA-binding protein, putative |
Plasmodium yoelii | PY04674 | similar to proteasome 26S subunit, non-ATPase, 10-related |
Schistosoma japonicum | Sjp_0070420 | Acyl-CoA-binding domain-containing protein 6, putative |
Schistosoma mansoni | Smp_147930 | acyl-coenzyme A binding domain containing |
Schmidtea mediterranea | mk4.015307.00 | |
Schmidtea mediterranea | mk4.006585.02 | |
Schmidtea mediterranea | mk4.006585.03 | |
Toxoplasma gondii | TGME49_234510 | ankyrin repeat-containing protein |
Theileria parva | TP01_0745 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0929100 | Plasmodium berghei | Slow | plasmo |
TGME49_234510 | Toxoplasma gondii | Essentiality uncertain | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.