Detailed view for Smp_188660

Basic information

TDR Targets ID: 289473
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 8.3308 | Length (AA): 163 | MW (Da): 18258 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0016192   vesicle-mediated transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128864)

Species Accession Gene Product
Arabidopsis thaliana AT4G36630   protein EMBRYO DEFECTIVE 2754
Brugia malayi Bm1_00995   hypothetical protein
Candida albicans CaO19.1568   similar to C terminus of S. cerevisiae Rab guanyl-nucleotide exchange factor VAM6 (YDL077C) involved in vacuolar morphogenesis
Candida albicans CaO19.9141   similar to C terminus of S. cerevisiae Rab guanyl-nucleotide exchange factor VAM6 (YDL077C) involved in vacuolar morphogenesis
Candida albicans CaO19.1567   similar to N terminus of S. pombe VAM6-like putative vacuolar protein vps39 (SPAC23H4.14)
Candida albicans CaO19.9140   similar to N terminus of S. pombe VAM6-like putative vacuolar protein vps39 (SPAC23H4.14)
Caenorhabditis elegans CELE_T08G5.5   Protein VPS-39, isoform C
Dictyostelium discoideum DDB_G0279169   citron-like domain-containing protein
Drosophila melanogaster Dmel_CG7146   Vacuolar protein sorting 39
Echinococcus granulosus EgrG_001200800   Vam6:Vps39 protein
Echinococcus multilocularis EmuJ_001200800   Vam6:Vps39 protein
Homo sapiens ENSG00000166887   vacuolar protein sorting 39 homolog (S. cerevisiae)
Leishmania braziliensis LbrM.20.6010   hypothetical protein, conserved
Leishmania donovani LdBPK_120910.1   Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative
Leishmania infantum LinJ.12.0910   hypothetical protein, conserved
Leishmania major LmjF.12.1320   hypothetical protein, conserved
Leishmania mexicana LmxM.12.1320   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_10497   hypothetical protein
Loa Loa (eye worm) LOAG_11035   hypothetical protein
Mus musculus ENSMUSG00000027291   vacuolar protein sorting 39 (yeast)
Oryza sativa 4333909   Os03g0715500
Saccharomyces cerevisiae YDL077C   Vam6p
Schistosoma japonicum Sjp_0209840   expressed protein
Schistosoma japonicum Sjp_0116730   hypothetical protein
Schistosoma mansoni Smp_193210   hypothetical protein
Schistosoma mansoni Smp_192990   hypothetical protein
Schistosoma mansoni Smp_188660   hypothetical protein
Schistosoma mansoni Smp_034210   vam6/vps39 related
Schmidtea mediterranea mk4.010238.00  
Schmidtea mediterranea mk4.015131.01  
Trypanosoma brucei gambiense Tbg972.1.3280   hypothetical protein, conserved
Trypanosoma brucei Tb927.1.4760   Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative
Trypanosoma congolense TcIL3000_1_1970   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507997.60   Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative
Trypanosoma cruzi TcCLB.508593.50   Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative
Trypanosoma cruzi TcCLB.508823.90   hypothetical protein
Trichomonas vaginalis TVAG_027270   conserved hypothetical protein

Essentiality

Smp_188660 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.4760 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.4760 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.4760 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.4760 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T08G5.5 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_188660 (Schistosoma mansoni), hypothetical protein
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