Detailed view for Smp_052790

Basic information

TDR Targets ID: 289593
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.496 | Length (AA): 1009 | MW (Da): 116276 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05670   Domain of unknown function (DUF814)
PF05833   Fibronectin-binding protein A N-terminus (FbpA)
PF11923   Domain of unknown function (DUF3441)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 177 5h3x (A) 2 183 18.00 0.000000000062 0.49 0.336348 0
162 924 5b43 (A) 145 834 14.00 0 0.96 0.579594 1.59
168 989 5hb4 (B) 707 1545 10.00 0 0.04 0.709068 0.8
332 421 5j0l (A) 16 109 31.00 0.16 0.44 0.481797 -0.86
692 869 4uos (A) 1 176 10.00 0.19 0 0.351312 -1.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127300)

Species Accession Gene Product
Arabidopsis thaliana AT5G49930   protein EMBRYO DEFECTIVE 1441
Babesia bovis BBOV_IV001930   conserved hypothetical protein
Brugia malayi Bm1_11010   Serologically defined colon cancer antigen 1
Candida albicans CaO19.10114   same as cosmid orf Ca49C4.10c
Candida albicans CaO19.2582   same as cosmid orf Ca49C4.10c
Caenorhabditis elegans CELE_Y82E9BR.18   Protein Y82E9BR.18
Cryptosporidium hominis Chro.50204   hypothetical protein
Cryptosporidium parvum cgd5_1780   MJ1625/yease Yp1009cp-like HhH domain
Dictyostelium discoideum DDB_G0289583   DUF814 family protein
Drosophila melanogaster Dmel_CG11847   Caliban
Echinococcus granulosus EgrG_001091400   protein of unknown function DUF814
Entamoeba histolytica EHI_007320   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_001091400   protein of unknown function DUF814
Giardia lamblia GL50803_4043   Serologically defined colon cancer antigen 1
Homo sapiens 9147   nuclear export mediator factor
Leishmania braziliensis LbrM.09.0990   hypothetical protein, conserved
Leishmania donovani LdBPK_090990.1   hypothetical protein, conserved
Leishmania infantum LinJ.09.0990   hypothetical protein, conserved
Leishmania major LmjF.09.0940   hypothetical protein, conserved
Leishmania mexicana LmxM.09.0940   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_07995   serologically defined colon cancer antigen 1
Mus musculus ENSMUSG00000020982   nuclear export mediator factor
Neospora caninum NCLIV_051350   hypothetical protein
Oryza sativa 4352539   Os12g0564600
Onchocerca volvulus OVOC2214   Nuclear export mediator factor NEMF homolog
Onchocerca volvulus OVOC7568   Nuclear export mediator factor NEMF homolog
Plasmodium berghei PBANKA_0601600   conserved protein, unknown function
Plasmodium falciparum PF3D7_1202600   conserved protein, unknown function
Plasmodium knowlesi PKNH_1302500   conserved protein, unknown function
Plasmodium vivax PVX_084175   hypothetical protein, conserved
Plasmodium yoelii PY01520   strong similarity to unknown protein-related
Saccharomyces cerevisiae YPL009C   Tae2p
Schistosoma japonicum Sjp_0026100   Serologically defined colon cancer antigen 1 homolog, putative
Schistosoma mansoni Smp_052790   hypothetical protein
Schmidtea mediterranea mk4.004920.06   Nuclear export mediator factor NEMF
Trypanosoma brucei gambiense Tbg972.11.14530   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.13060   translation-associated element 2, putative
Trypanosoma congolense TcIL3000.11.13430   translation-associated element 2, putative
Trypanosoma congolense TcIL3000_0_05480   Domain of unknown function (DUF3441), putative
Trypanosoma cruzi TcCLB.507483.60   translation-associated element 2, putative
Trypanosoma cruzi TcCLB.506389.70   translation-associated element 2, putative
Toxoplasma gondii TGME49_214090   signal peptidase
Theileria parva TP03_0467   hypothetical protein, conserved
Trichomonas vaginalis TVAG_198060   conserved hypothetical protein

Essentiality

Smp_052790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.4630 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.4630 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.4630 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.4630 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_214090 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_052790 (Schistosoma mansoni), hypothetical protein
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