Detailed view for Smp_175740.2

Basic information

TDR Targets ID: 289660
Schistosoma mansoni, 60S ribosomal protein L14
Source Database / ID:  GeneDB

pI: 11.2508 | Length (AA): 146 | MW (Da): 17045 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01929   Ribosomal protein L14

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
7 88 2joy (A) 3 86 28.00 0 1 0.961544 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127132)

Species Accession Gene Product
Arabidopsis thaliana AT4G27090   60S ribosomal protein L14-2
Arabidopsis thaliana AT2G20450   60S ribosomal protein L14-1
Babesia bovis BBOV_IV010510   ribosomal protein L14, putative
Brugia malayi Bm1_09490   60S ribosomal protein L14
Caenorhabditis elegans CELE_C04F12.4   Protein RPL-14
Cryptosporidium hominis Chro.30157   60S ribosomal protein L14
Cryptosporidium parvum cgd3_1250   ribosomal protein L14
Dictyostelium discoideum DDB_G0277975   S60 ribosomal protein L14
Drosophila melanogaster Dmel_CG6253   Ribosomal protein L14
Echinococcus granulosus EgrG_000921300   60S ribosomal protein L14
Entamoeba histolytica EHI_184470   60S ribosomal protein L14, putative
Entamoeba histolytica EHI_185580   60S ribosomal protein L14, putative
Echinococcus multilocularis EmuJ_000921300   60S ribosomal protein L14
Giardia lamblia GL50803_14091   Ribosomal protein L14
Homo sapiens ENSG00000188846   ribosomal protein L14
Leishmania braziliensis LbrM.22.1420   40S ribosomal protein L14, putative
Leishmania braziliensis LbrM.22.1460   40S ribosomal protein L14, putative
Leishmania donovani LdBPK_221370.1   40S ribosomal protein L14, putative
Leishmania infantum LinJ.22.1410   40S ribosomal protein L14, putative
Leishmania infantum LinJ.22.1370   40S ribosomal protein L14, putative
Leishmania major LmjF.22.1520   40S ribosomal protein L14, putative
Leishmania major LmjF.22.1560   40S ribosomal protein L14, putative
Leishmania mexicana LmxM.22.1560   40S ribosomal protein L14, putative
Leishmania mexicana LmxM.22.1520   40S ribosomal protein L14, putative
Loa Loa (eye worm) LOAG_03621   60S ribosomal protein L14
Mus musculus ENSMUSG00000025794   ribosomal protein L14
Neospora caninum NCLIV_039030   hypothetical protein
Oryza sativa 4336397   Os04g0515300
Oryza sativa 4330020   Os02g0622300
Plasmodium berghei PBANKA_1013100   60S ribosomal protein L14, putative
Plasmodium falciparum PF3D7_1431700   60S ribosomal protein L14, putative
Plasmodium knowlesi PKNH_1327000   60S ribosomal protein L14, putative
Plasmodium vivax PVX_084955   60S ribosomal protein L14, putative
Plasmodium yoelii PY02173   60S ribosomal protein L14
Saccharomyces cerevisiae YHL001W   ribosomal 60S subunit protein L14B
Saccharomyces cerevisiae YKL006W   ribosomal 60S subunit protein L14A
Schistosoma japonicum Sjp_0306910   ko:K02875 large subunit ribosomal protein L14e, putative
Schistosoma mansoni Smp_175740.1   60S ribosomal protein L14
Schistosoma mansoni Smp_175740.2   60S ribosomal protein L14
Schmidtea mediterranea mk4.007901.00   60S ribosomal protein L14
Trypanosoma brucei gambiense Tbg972.11.12550   40S ribosomal protein L14, putative
Trypanosoma brucei gambiense Tbg972.6.410   40S ribosomal protein L14, putative
Trypanosoma brucei Tb927.11.11230   60S ribosomal protein L14, putative
Trypanosoma brucei Tb927.6.720   40S ribosomal protein L14, putative
Trypanosoma congolense TcIL3000.11.11880   60S ribosomal protein L14, putative
Trypanosoma congolense TcIL3000_6_270   60S ribosomal protein L14, putative
Trypanosoma cruzi TcCLB.511825.200   60S ribosomal protein L14, putative
Trypanosoma cruzi TcCLB.506937.30   60S ribosomal protein L14, putative
Trypanosoma cruzi TcCLB.510437.20   60S ribosomal protein L14, putative
Trypanosoma cruzi TcCLB.506861.30   60S ribosomal protein L14, putative
Toxoplasma gondii TGME49_267060   ribosomal protein RPL14
Theileria parva TP01_0675   60S ribosomal protein L14, putative
Trichomonas vaginalis TVAG_262730   60S ribosomal protein L14, putative
Trichomonas vaginalis TVAG_353710   60S ribosomal protein L14, putative
Trichomonas vaginalis TVAG_026460   60S ribosomal protein L14, putative

Essentiality

Smp_175740.2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.720 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.720 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.6.720 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.6.720 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.3020 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.01.3020 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.3020 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.01.3020 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C04F12.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_C04F12.4 Caenorhabditis elegans larval arrest wormbase
CELE_C04F12.4 Caenorhabditis elegans slow growth wormbase
CELE_C04F12.4 Caenorhabditis elegans sterile wormbase
PBANKA_1013100 Plasmodium berghei Essential plasmo
TGME49_267060 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_175740.2 (Schistosoma mansoni), 60S ribosomal protein L14
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