Detailed view for Smp_140010

Basic information

TDR Targets ID: 289717
Schistosoma mansoni, eukaryotic translation initiation factor 2c
Source Database / ID:  GeneDB

pI: 9.606 | Length (AA): 876 | MW (Da): 97965 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02170   PAZ domain
PF02171   Piwi domain
PF08699   Argonaute linker 1 domain
PF16486   N-terminal domain of argonaute
PF16487   Mid domain of argonaute
PF16488   Argonaute linker 2 domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 86 4q1q (A) 238 311 19.00 0 0.07 0.380275 -1.13
17 78 3s6l (A) 13 74 32.00 0.084 0.08 0.470776 -0.85
29 79 2pne (A) 7 60 45.00 0.0099 0.47 0.318219 -0.56
90 876 4kre (A) 20 857 48.00 0 1 1.3622 0.15
91 876 4kre (A) 21 857 67.00 0 1 1.53426 -0.2
281 448 1r4k (A) 297 464 87.00 0 1 1.11878 0.3
336 405 3mj0 (A) 652 715 42.00 0.000043 1 0.555909 -0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127240)

Species Accession Gene Product
Arabidopsis thaliana AT2G27880   argonaute 5
Arabidopsis thaliana AT5G43810   eIF2C family protein Argonaute10
Arabidopsis thaliana AT1G48410   protein argonaute 1
Brugia malayi Bm1_13960   argonaute 2
Candida albicans CaO19.2903   similar to C terminal region of several plant Argonaute-like proteins and to S. pombe ago1 (SPCC736.11)
Candida albicans CaO19.10421   similar to C terminal region of several plant Argonaute-like proteins and to S. pombe ago1 (SPCC736.11)
Candida albicans CaO19.10422   hypothetical protein
Candida albicans CaO19.2904   hypothetical protein
Caenorhabditis elegans CELE_F48F7.1   Protein ALG-1, isoform B
Caenorhabditis elegans CELE_T07D3.7   Protein ALG-2, isoform A
Drosophila melanogaster Dmel_CG6671   Argonaute-1
Echinococcus granulosus EgrG_000346200   Eukaryotic translation initiation factor 2C 2
Echinococcus multilocularis EmuJ_000346200   Eukaryotic translation initiation factor 2C 2
Homo sapiens ENSG00000123908   argonaute RISC catalytic component 2
Homo sapiens ENSG00000134698   argonaute RISC catalytic component 4
Homo sapiens ENSG00000126070   argonaute RISC catalytic component 3
Homo sapiens 26523   argonaute RISC catalytic component 1
Loa Loa (eye worm) LOAG_07436   argonaute 2
Mus musculus 214150   argonaute RISC catalytic subunit 3
Mus musculus ENSMUSG00000041530   argonaute RISC catalytic subunit 1
Mus musculus ENSMUSG00000042500   argonaute RISC catalytic subunit 4
Mus musculus 239528   argonaute RISC catalytic subunit 2
Neospora caninum NCLIV_054260   hypothetical protein
Oryza sativa 9270411   Os04g0566500
Oryza sativa 4333732   Os03g0682200
Oryza sativa 4331253   Os02g0831600
Oryza sativa 4330281   Os02g0672200
Oryza sativa 4342138   Os06g0729300
Oryza sativa 4333733   Os03g0682600
Oryza sativa 9269807   Os02g0616501
Oryza sativa 4328436   Os02g0169400
Oryza sativa 9269490   Os06g0597400
Oryza sativa 4342603   Os07g0188000
Oryza sativa 4343201   Os07g0471300
Oryza sativa 4334449   Os03g0800200
Onchocerca volvulus OVOC12671  
Schistosoma japonicum Sjp_0044720   Eukaryotic translation initiation factor 2C 2, putative
Schistosoma mansoni Smp_140010   eukaryotic translation initiation factor 2c
Schmidtea mediterranea mk4.008596.00  
Schmidtea mediterranea mk4.008596.01   AGO-2
Schmidtea mediterranea mk4.036615.00  
Toxoplasma gondii TGME49_310160   argonaute AGO

Essentiality

Smp_140010 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F48F7.1 Caenorhabditis elegans embryonic arrest wormbase
CELE_F48F7.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F48F7.1 Caenorhabditis elegans larval lethal wormbase
CELE_F48F7.1 Caenorhabditis elegans slow growth wormbase
CELE_F48F7.1 Caenorhabditis elegans sterile wormbase
CELE_T07D3.7 Caenorhabditis elegans embryonic arrest wormbase
CELE_T07D3.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T07D3.7 Caenorhabditis elegans larval lethal wormbase
CELE_T07D3.7 Caenorhabditis elegans sterile wormbase
TGME49_310160 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_140010 (Schistosoma mansoni), eukaryotic translation initiation factor 2c
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