Detailed view for Smp_082940
Basic information
Schistosoma mansoni, NADH-ubiquinone oxidoreductase
Source Database / ID: GeneDB
pI: 9.3818 |
Length (AA): 136 |
MW (Da): 16364 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0016020 membrane
GO:0009055 electron carrier activity
Metabolic Pathways
Structural information
Modbase 3D models:
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_129850)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G03100 | putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 |
| Brugia malayi | Bm1_36520 | NADH-ubiquinone oxidoreductase subunit B17.2 |
| Candida albicans | CaO19.1625 | similar to N. crassa orf (CAD21387) |
| Candida albicans | CaO19.9193 | similar to N. crassa orf (CAD21387) |
| Caenorhabditis elegans | CELE_Y94H6A.8 | Protein Y94H6A.8 |
| Dictyostelium discoideum | DDB_G0285783 | NADH dehydrogenase ubiquinone 1 alpha subcomplex subunit 12 |
| Drosophila melanogaster | Dmel_CG3214 | CG3214 gene product from transcript CG3214-RB |
| Echinococcus granulosus | EgrG_000795900 | NADH:ubiquinone oxidoreductase |
| Echinococcus multilocularis | EmuJ_000795900 | NADH:ubiquinone oxidoreductase |
| Homo sapiens | ENSG00000184752 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 |
| Mus musculus | ENSMUSG00000020022 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 |
| Oryza sativa | 4349513 | Os10g0579300 |
| Schistosoma japonicum | Sjp_0011220 | ko:K00329 NADH dehydrogenase [EC1.6.5.3], putative |
| Schistosoma mansoni | Smp_082940 | NADH-ubiquinone oxidoreductase |
| Wolbachia endosymbiont of Brugia malayi | Wbm0017 | NADH:ubiquinone oxidoreductase subunit |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References